Synthesis and antiproliferative activity of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives

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dc.contributor.authorDemirayak, Şeref
dc.contributor.authorYurttaş, Leyla
dc.contributor.authorKaraburun, Ahmet Cağrı
dc.contributor.authorGündoğdu Karaburun, Nalan
dc.contributor.authorKayagil, İsmail
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:39Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:39Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.descriptionWOS: 000389460600011
dc.description.abstractThe synthesis of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives was reported and selected compounds were determined for their anticancer activity evaluation in National Cancer Institute NCI, USA according to the drug screening protocol of the institute against approximately 60 tumor cell lines derived from nine cancer diseases. Compound 3r, namely 2-(4-chlorobenzylidene)- 6-[2-(4-methoxyphenyl)-2-oxoethoxy] benzofuran-3-one exhibited the highest antitumor activity against non-small lung cancer cell lines.
dc.description.sponsorshipAnadolu University, Turkey (BAP Project) [050301]en_US
dc.description.sponsorshipThe study was financially supported by Anadolu University, Turkey (BAP Project No: 050301). The authors present their thanks to NCI (USA) and Anadolu University BIBAM (Turkiye) for anticancer test results and NMR spectra, respectively.en_US
dc.identifier.citationDemirayak, Ş., Yurttaş, L., Karaburun, A. Ç., Gündoğdu Karaburun, N. ve Kayagil, İ. (2016). Synthesis and antiproliferative activity of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives. Letters In Drug Design & Discovery, 13(6), 563-569. https://dx.doi.org/10.2174/1570180813999160429113316
dc.identifier.doi10.2174/1570180813999160429113316
dc.identifier.endpage569
dc.identifier.issn1570-1808
dc.identifier.issn1875-628X
dc.identifier.issue6
dc.identifier.scopusqualityQ2
dc.identifier.startpage563
dc.identifier.urihttps://dx.doi.org/10.2174/1570180813999160429113316
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3382
dc.identifier.volume13
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofLetters In Drug Design & Discoveryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAntitumor Activity
dc.subjectAurone
dc.subjectBenzofuranone
dc.subjectChalcone
dc.subjectCytotoxic Activity
dc.titleSynthesis and antiproliferative activity of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives
dc.typeArticle

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