Synthesis, antimicrobial activity studies and molecular property predictions of schiff bases derived from ortho-vanillin

Basit Öğe Kaydı
dc.authorid0000-0001-6047-2796
dc.authorid0000-0002-2289-7950
dc.authorid0000-0003-1896-2729
dc.contributor.authorBerk, Barkın
dc.contributor.authorErtaş, Merve
dc.contributor.authorBiltekin, Sevde Nur
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:13Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:13Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractSchiff bases are known to possess anticancer, antibacterial, antifungal, antitubercular, anti-inflammatory, antibacterial and antimalarial properties. At the same time, in recent years, prediction of drug-likeness, molecular, absorption, distribution, metabolism, and excretion (ADME) properties using in silico techniques has become a standard procedure for the evaluation of clinical usable molecules. In this study, Schiff base structured 2-methoxy-6-{[(2-alkyl/arylethyl)imino]methyl}phe-nol derivatives were synthesized from 3-methoxysalicylaldehyde (o-vanillin). The antibacterial and antifungal activities of these compounds were determined against Staphylococcus aureus, Escherichia coli, Candida albicans and Pseudomonas aeruginosa using agar-well diffusion and broth microdilution techniques. Further analysis was conducted using the in silico technique to predict the drug-likeness, molecular and ADME properties of these molecules. Among all the compounds, 2-{[(4-fluorophenethyl)imino]methyl}-6-methoxyphenol (Compound 9) exhibited the highest activity with good minimum inhibition concentration and radius of inhibition zone values against Candida albicans.
dc.identifier.citationBerk, B., Ertaş, M. ve Biltekin, S. N. (2017). Synthesis, antimicrobial activity studies and molecular property predictions of schiff bases derived from ortho-vanillin. Acta Pharmaceutica Sciencia, 55(1), 83-96. https://dx.doi.org/10.23893/1307-2080.APS.0556
dc.identifier.doi10.23893/1307-2080.APS.0556
dc.identifier.endpage96
dc.identifier.issn1307-2080
dc.identifier.issue1
dc.identifier.scopusqualityQ4
dc.identifier.startpage83
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1096
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.0556
dc.identifier.volume55
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversity of Istanbul
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntifungal
dc.subjectCandida Albicans
dc.subjectIn Silico
dc.subjectMolecular Properties
dc.subjectSchiff Bases
dc.titleSynthesis, antimicrobial activity studies and molecular property predictions of schiff bases derived from ortho-vanillin
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Barkın- Berk(2017).pdf
Boyut:
240.73 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Eczacılık Fakültesi Makale Koleksiyonu