Synthesis, antimicrobial and anticancer activities of some naphthylthiazolylamine derivatives

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dc.authorid0000-0002-0841-1299
dc.contributor.authorTay, Funda
dc.contributor.authorErkan, Celal
dc.contributor.authorYılmaz Sarıözlü, Nalan
dc.contributor.authorErgene. Emel
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:28Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:28Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.description13th International Symposium on Wireless Communication Systems, ISWCS 2016
dc.description20 September 2016 through 23 September 2016
dc.description124401
dc.description.abstractNew 4-naphthyl-2-aminothiazole derivatives were synthesized. The newly synthesized compounds were screened for their in vitro antimicrobial and anticancer activities. The results indicated that compound 5b namely 2-(4-methylpiperidine-1-yl)-4-(naphthalene-2-yl) thiazole exhibited highest MIC value (62.5 µg/ml) against P. aeruginosa in the tested microorganisms. This compound showed equipotent antifungal effect on C. albicans and C. glabrata as compared with ketoconazole. Compounds 4c, 4d, 5a and 5f showed remarkably antifungal activity against C. albicans. In addition, anticancer activity and cytotoxicity studies were also carried out in Hep-G2 and A549 cell lines to examine the ability of inhibiting the cell growth for 4a-4f and 5a-5f compounds. The cell viability and anticancer activity were determined by MTT assay. 4a-4f compounds has led to an increase in cell proliferation in both cell lines (Hep-G2 and A549 cells), unlike 5a-5f series showed a weak anticancer activity.
dc.description.sponsorshipEskisehir Osmangazi Universityen_US
dc.identifier.citationTay, F., Erkan, C., Yılmaz Sarıözlü, N., Ergene, E. ve Demirayak, Ş. (2017). Synthesis, antimicrobial and anticancer activities of some naphthylthiazolylamine derivatives. Biomedical Research-India, 28(6), 2696-2703.
dc.identifier.endpage2703
dc.identifier.issn0970-938X
dc.identifier.issue6
dc.identifier.scopusqualityQ4
dc.identifier.startpage2696
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1410
dc.identifier.volume28
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherScientific Publishers of India
dc.relation.ispartofBiomedical Research-Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntimicrobial Activity
dc.subjectCytotoxicity
dc.subjectMTT Assay
dc.subjectNaphthalene
dc.subjectThiazole
dc.titleSynthesis, antimicrobial and anticancer activities of some naphthylthiazolylamine derivatives
dc.typeArticle

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