Evaluation of neurological imaging after hematopoietic stem cell transplantation in adults

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dc.authorid0000-0002-6315-9620
dc.authorid0000-0002-4104-8508
dc.authorid0000-0001-6826-7818
dc.authorid0000-0001-6869-7682
dc.authorid0000-0002-3385-8359
dc.authorid0000-0003-1237-8281
dc.authorid0000-0001-9636-4113
dc.authorid0000-0002-1077-8540
dc.contributor.authorSadri, Sevil
dc.contributor.authorPolat, Burcu
dc.contributor.authorBalık Aydın, Berrin
dc.contributor.authorKoçar, Hakan
dc.contributor.authorGemici, Aliihsan
dc.contributor.authorBeköz, Hüseyin Saffet
dc.contributor.authorSevindik, Ömür Gökmen
dc.contributor.authorSargın, Fatma Deniz
dc.date.accessioned2022-08-22T07:25:04Z
dc.date.available2022-08-22T07:25:04Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractTo investigate the risk factors for, and the incidence of, structural abnormalities in brain imaging among hematopoetic stem cell transplant (HSCT) patients and to correlate these findings with physical examinations. This study retrospectively reviewed all post-HSCT brain imaging taken in the researchers’ center between 2014 and 2020. 87 of 627 transplant patients were imaged. 34.5% (n = 30) were female. Age at transplant ranged from 18 to 74 years (median: 45). The most common malignancies were acute myeloid leukemia (AML; n = 21; 24.1%), 51 (58.6%) patients received allogeneic transplantation, and 36 (41.4%) received autologous transplantation. The imaging techniques were dispersed as follows: magnetic resonance imaging (MRI): 83.9% (n = 73), brain computed tomography (CT): 37.9% (n = 33), diffusion MRI: 19.5% (n = 17). 39.1% of the radiological images were normal; 20.7% showed disease recurrence; and 14.9% detected ischemic gliotic lesions. According to the imaging results, there was a statistically s ignificant difference between age values (p = 0.013). Patients with PRES were younger than those with no pathologies in their imaging, while patients with infarcts and ischemic gliotic lesions were older than those with normal imaging (p = 0.001). Patien ts with disease recurrence were older than those with PRES but younger than those with infarctions (p = 0.001). Neurological complications are not uncommon in transplant cases. In managing transplantations, it should be remembered that the presence of radiologically positive findings, especially positives for cerebrovascular complications, can significantly reduce survival.
dc.identifier.citationSadri, S., Polat, B., Balık Aydın, B., Koçar, H., Gemici, A., Beköz, H. S. ... Sargın, F. D. (2022). Evaluation of neurological imaging after hematopoietic stem cell transplantation in adults. Eastern Journal of Medicine, 27(3), 437-445. http://doi.org/10.5505/ejm.2022.54765
dc.identifier.doi10.5505/ejm.2022.54765
dc.identifier.endpage445
dc.identifier.issn1301-0883
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85135566797
dc.identifier.scopusqualityQ4
dc.identifier.startpage437
dc.identifier.trdizinid1123902
dc.identifier.urihttp://doi.org/10.5505/ejm.2022.54765
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9663
dc.identifier.volume27
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorSadri, Sevil
dc.institutionauthorPolat, Burcu
dc.institutionauthorBalık Aydın, Berrin
dc.institutionauthorKoçar, Hakan
dc.institutionauthorGemici, Aliihsan
dc.institutionauthorBeköz, Hüseyin Saffet
dc.institutionauthorSevindik, Ömür Gökmen
dc.institutionauthorSargın, Fatma Deniz
dc.language.isoen
dc.publisherYüzüncü Yıl University Faculty of Medicine
dc.relation.ispartofEastern Journal of Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBrain Imaging
dc.subjectNeurological Complications
dc.subjectHematopoietic Stem Cell Transplantation
dc.subjectCerebrova Scular Complications
dc.titleEvaluation of neurological imaging after hematopoietic stem cell transplantation in adults
dc.typeArticle

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