NMDA receptor encephalitis with cancer of unknown primary origin

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dc.contributor.authorÇoban, Arzu
dc.contributor.authorGündoğdu, Gökçen
dc.contributor.authorPoyraz, Mürüvvet
dc.contributor.authorYeğen, Gülçin
dc.contributor.authorDemirtaş-Tatlıdede, Aslı
dc.contributor.authorBilgiç, Başar
dc.contributor.authorHanağası, Haşmet
dc.contributor.authorTüzün, Erdem
dc.contributor.authorGürvit, Hakan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:24Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:24Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.descriptionWOS: 000388282800002
dc.descriptionPubMed ID: 26481863
dc.description.abstractPurpose: N-methyl-D-aspartate receptor (NMDAR) encephalitis may present as a paraneoplastic syndrome in young women and is often associated with ovarian teratoma. Methods: We report 2 male cases of NMDAR encephalitis presenting with metastatic cancer of unknown primary origin. Results: Both patients showed cognitive dysfunction as well as other neurological symptoms, slow waves on EEG, and NMDAR antibodies in sera and CSF. Symptoms were effectively treated by pulse steroid and intravenous immunoglobulin treatment. The patients developed metastatic small cell neuroendocrine carcinoma of the parotid gland and inguinal metastatic squamous cell cancer shortly after their neurological episodes. Follow-up PET studies showed small cell lung cancer in the first patient while no primary origin could be found in the second patient. Conlusions: Our cases imply that NMDAR encephalitis may present with metastatic cancers that display slow progression rates and occur after encephalitis attacks.
dc.identifier.citationÇoban, A., Gündoğdu, G., Poyraz, M., Yeğen, G., Demirtaş Tatlıdede, A., Bilgiç, B. ... Gürvit, H. (2016). NMDA receptor encephalitis with cancer of unknown primary origin. Tumori, 102(Supplement 2), S3-S4. https://dx.doi.org/10.5301/tj.5000447
dc.identifier.doi10.5301/tj.5000447
dc.identifier.endpageS4
dc.identifier.issn0300-8916
dc.identifier.issn2038-2529
dc.identifier.scopusqualityQ3
dc.identifier.startpageS3
dc.identifier.urihttps://dx.doi.org/10.5301/tj.5000447
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3869
dc.identifier.volume102
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWichtig Publishing
dc.relation.ispartofTumorien_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutoimmune Encephalitis
dc.subjectIon Channel Antibody
dc.subjectMetastatic Tumor
dc.subjectNMDA Receptor
dc.titleNMDA receptor encephalitis with cancer of unknown primary origin
dc.typeOther

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