Computational studies of G protein-coupled receptor complexes: Structure and dynamics

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dc.authorid0000-0001-5950-3436
dc.contributor.authorŞensoy, Özge
dc.contributor.authorAlmeida, Jose G.
dc.contributor.authorShabbir, Javeria
dc.contributor.authorMoreira, Irina S.
dc.contributor.authorMorra, Giulia
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:03Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:03Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.descriptionWOS: 000414418200017
dc.descriptionPubMed ID: 28964337
dc.description.abstractG protein-coupled receptors (GPCRs) are ubiquitously expressed transmembrane proteins associated with a wide range of diseases such as Alzheimer's, Parkinson, schizophrenia, and also implicated in in several abnormal heart conditions. As such, this family of receptors is regarded as excellent drug targets. However, due to the high number of intracellular signaling partners, these receptors have a complex interaction networks and it becomes challenging to modulate their function. Experimentally determined structures give detailed information on the salient structural properties of these signaling complexes but they are far away from providing mechanistic insights into the underlying process. This chapter presents some of the computational tools, namely molecular dynamics, molecular docking, and molecular modeling and related analyses methods that have been used to complement experimental findings.
dc.identifier.citationŞensoy, Ö., Almeida, J. G., Shabbir, J., Moreira, I. S. ve Morra, G. (2017). Computational studies of G protein-coupled receptor complexes: Structure and dynamics. G Protein-Coupled Receptors, 2nd Edition, Pt A içinde (205-245. ss.). https://dx.doi.org/10.1016/bs.mcb.2017.07.011
dc.identifier.doi10.1016/bs.mcb.2017.07.011
dc.identifier.endpage245
dc.identifier.isbn9780128133194
dc.identifier.issn0091-679X
dc.identifier.scopusqualityN/A
dc.identifier.startpage205
dc.identifier.urihttps://dx.doi.org/10.1016/bs.mcb.2017.07.011
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2547
dc.identifier.volume142
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Academic Press Inc
dc.relation.ispartofG Protein-Coupled Receptors, 2nd Edition, Pt Aen_US
dc.relation.ispartofseriesMethods in Cell Biology
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectStructure and Dynamics
dc.subjectG Protein
dc.subjectReceptor Complexes
dc.titleComputational studies of G protein-coupled receptor complexes: Structure and dynamics
dc.typeBook Chapter

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