The effect of gender on disease activity and clinical characteristics in patients with axial psoriatic arthritis

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dc.authorid0000-0002-1111-3110
dc.contributor.authorNas, Kemal
dc.contributor.authorKılıç, Erkan
dc.contributor.authorTekeoğlu, İbrahim
dc.contributor.authorKeskin, Yaşar
dc.contributor.authorÇevik, Remzi
dc.contributor.authorSargın, Betül
dc.contributor.authorAcer Kasman, Sevtap
dc.contributor.authorAlkan, Hakan
dc.contributor.authorŞahin, Nilay
dc.contributor.authorCengiz, Gizem
dc.contributor.authorCüzdan, Nihan
dc.contributor.authorAlbayrak Gezer, İlknur
dc.contributor.authorKeskin, Dilek
dc.contributor.authorMülkoğlu, Cevriye
dc.contributor.authorReşorlu, Hatice
dc.contributor.authorAtaman, Şebnem
dc.contributor.authorBal, Ajda
dc.contributor.authorBaykul, Merve
dc.contributor.authorDuruöz, Mehmet Tuncay
dc.contributor.authorKüçükakkaş, Okan
dc.contributor.authorYurdakul, Ozan Volkan
dc.contributor.authorAlkan Melikoğlu, Meltem
dc.contributor.authorAyhan, Fikriye Figen
dc.contributor.authorBodur, Hatice
dc.contributor.authorÇalış, Mustafa
dc.contributor.authorÇapkın, Erhan
dc.contributor.authorDevrimsel, Gül
dc.contributor.authorGök, Kevser
dc.contributor.authorHizmetli, Sami
dc.contributor.authorKamanlı, Ayhan
dc.contributor.authorKocabaş, Hilal
dc.contributor.authorKutluk, Öznur
dc.contributor.authorŞen, Nesrin
dc.contributor.authorŞendur, Ömer Faruk
dc.contributor.authorToprak, Murat
dc.contributor.authorTolu, Sena
dc.contributor.authorTuncer, Tiraje
dc.date.accessioned2021-10-20T11:49:03Z
dc.date.available2021-10-20T11:49:03Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalı
dc.description.abstractObjectives In this study, we aimed to evaluate the effect of gender on clinical findings, disease activity, functional status and quality of life in patients with axial involvement in Turkey. Methods Patients with PsA who met the CASPAR classification criteria were enrolled consequently in this cohort. Turkish League Against Rheumatism (TLAR)-Network was formed with the participation of 25 centres. The demographic variables, fatigue, diagnostic delay, the beginning of peripheral arthritis, enthesitis, dactylitis and spine involvement, inflammatory low back pain, BASFI, HAQ, HAQ-s, visual analogue scale-pain (VAS-pain), anxiety, depression and disease activity parameters (ESR, DAS28, BASDAI) were recorded. Axial involvement was assessed according to clinical and radiological data according to modified New York (MNYC) or Assessment of SpondyloArthritis international Society (ASAS) criteria. Results A total of 1018 patients with PsA were included in this study. Of the 373 patients with axial involvement, 150 were male (40.2%) and 223 (59.8%) were female. Spondylitis was detected in 14,7% of men and 21,9% of women in all patients. Pain score (VAS) (p < .002), fatigue (p < .001), ESR (p < .001), DAS28 (p < .001), BASDAI score (p < .001), PsAQoL (p < .001), HAQ score (p < ,01), HAQ-S score (p < .001), anxiety (p < .001), depression (p < .024), FACIT (p < .001) and FiRST (p < .001) scores were statistically significantly worse in women than males with axial PsA. However, quality of life was better (p < .001) and PASI score (p < .005) were statistically worse in male patients than in female patients with axial involvement. Conclusion This study has shown that the burden of disease in axial PsA has significant difference between genders. Disease activity, physical disability, functional limitation, depression and anxiety scores were higher in female patients, while quality of life were better and PASI score were higher in male patients. Therefore, we suggest that new strategies should be developed for more effective treatment of axial PsA in female patients.
dc.identifier.citationNas, K., Kılıç, E., Tekeoğlu, İ., Keskin, Y., Çevik, R., Sargın, B. ... Tuncer, T. (2021). The effect of gender on disease activity and clinical characteristics in patients with axial psoriatic arthritis. Modern Rheumatology, 31(4), 869-874. https://dx.doi.org/10.1080/14397595.2020.1812870
dc.identifier.doi10.1080/14397595.2020.1812870
dc.identifier.endpage874
dc.identifier.issn1439-7595
dc.identifier.issn1439-7609
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage869
dc.identifier.urihttps://dx.doi.org/10.1080/14397595.2020.1812870
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8489
dc.identifier.volume31
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofModern Rheumatologyen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAxial Involvement
dc.subjectGender
dc.subjectPsoriatic Arthritis
dc.subjectQuality of Life
dc.subjectRisk Factors
dc.titleThe effect of gender on disease activity and clinical characteristics in patients with axial psoriatic arthritis
dc.typeReview Article

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