Proconvulsant effect of papaverine on penicillin-induced epileptiform activity in rats

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dc.contributor.authorMarangoz, Abdullah Hilmi
dc.contributor.authorKocacan, Süleyman Emre
dc.contributor.authorHim, Aydın
dc.contributor.authorKuruoğlu, Enis
dc.contributor.authorÇokluk, Cengiz
dc.contributor.authorMarangoz, Cafer
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:04:12Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:04:12Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.descriptionWOS: 000435231900022
dc.descriptionPubMed ID: 28944941
dc.description.abstractAIM: Papaverine is a vasodilator agent that is an opium alkaloid. It exhibits its effects by inhibiting the phosphodiesterase enzyme. Papaverine administration is widely used to avoid symptomatic vasospasm after subarachnoid hemorrhage. We aimed, in this research, to study the effects of papaverine on the epileptic discharges stimulated by penicillin. MATERIAL and METHODS: Adult female Wistar rats (220 +/- 30 g) were included in this research (n= 30). Rats were anesthetized with urethane (1.25 g/kg) and then the left cerebral cortex was reached by opening a burr hole with a drill. Penicillin G sodium salt (500 IU)(200 IU/1 mu l) was injected into the left lateral ventricle to produce epileptiform activity. Thirty minutes before penicillin G sodium injection, papaverine was administered at doses of 5, 10, 20 or 40 mg/kg intraperitoneally. RESULTS: There was no significant difference in spike frequency between the control group and the groups given 5 mg/kg, 10 mg/kg or 40 mg/kg papaverine, while 20 mg/kg papaverine significantly increased the spike frequency (p<0.05). CONCLUSION: Papaverine augments the epileptiform activity produced by penicillin injection. It is important to remember that papaverine might induce convulsions in patients who have epilepsy. More research is required to understand the mechanisms of the proconvulsant influence of papaverine in epilepsy.
dc.identifier.citationMarangoz, A. H., Kocacan, S. E., Him, A., Kuruoğlu, E., Çokluk, C. ve Marangoz, C. (2018). Proconvulsant effect of papaverine on penicillin-induced epileptiform activity in rats. Turkish Neurosurgery, 28(3), 479-482. https://dx.doi.org/10.5137/1019-5149.JTN.19703-17.2
dc.identifier.doi10.5137/1019-5149.JTN.19703-17.2
dc.identifier.endpage482
dc.identifier.issn1019-5149
dc.identifier.issue3
dc.identifier.scopusqualityQ3
dc.identifier.startpage479
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.19703-17.2
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4012
dc.identifier.volume28
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Society
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpilepsy
dc.subjectFemale Rat
dc.subjectPapaverine
dc.subjectPenicillin
dc.titleProconvulsant effect of papaverine on penicillin-induced epileptiform activity in rats
dc.typeArticle

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