Effect of glabridin on microvascular permeability of plasma proteins induced by carrageenan

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dc.authorid0000-0003-0052-3648
dc.contributor.authorParlar Köprülü, Rabia Edibe
dc.contributor.authorParlar, Ali
dc.contributor.authorÇam, Saliha Ayşenur
dc.contributor.authorArslan, Seyfullah Oktay
dc.date.accessioned2022-01-10T06:55:24Z
dc.date.available2022-01-10T06:55:24Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı
dc.description.abstractIn present study, investigate the anti-inflammatory effects of glabridin (GLA) in the carrageenan-induced paw edema test of rats. Inflammation is an answer to the body's immune response to various stimuli such as physical trauma, various antigens chemicals, microorganisms radiation- damaged tissues. The cause of this edema is the increase of vascular permeability. an increase in local blood flow as well as the penetration of neutrophils and macrophages into the inflamed tissue. The current study aimed to determine the mechanism of microvascular leakage on carrageenan (CAR)-induced paw. edema of GLA. Therefore 10, 20 and 40 mg/kg doses of GLA were given intraperitoneal 3 days before intraplantar administration of CAR by using Evans blue (EB) method and by measuring paw thickness with electronic digital calipers. As a result, GLA inhibited both edema and microvascular leak. The results of our study suggest that pretreat-GLA to CAR -induced paw edema of rats via anti-inflammatory potential through inhibition of parameters such as microvascular escape and anti-edematous effect. These findings may be a new treatment of inflammation by anti-protein leakage of GLA.
dc.identifier.citationParlar Köprülü, R. E., Parlar, A., Çam, S. A. ve Arslan, S. O. (2022). Effect of glabridin on microvascular permeability of plasma proteins induced by carrageenan. Biointerface Research in Applied Chemistry, 12(2), 2415-2421. https://doi.org/10.33263/BRIAC122.24152421
dc.identifier.doi10.33263/BRIAC122.24152421
dc.identifier.endpage2421
dc.identifier.issn2069-5837
dc.identifier.issue2
dc.identifier.scopusqualityQ3
dc.identifier.startpage2415
dc.identifier.urihttps://doi.org/10.33263/BRIAC122.24152421
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8788
dc.identifier.volume12
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBiointerface Research in Applied Chemistry
dc.relation.ispartofBiointerface Research in Applied Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectGlabridin
dc.subjectInflammation
dc.subjectEvans Blue Dye
dc.subjectCarrageenan
dc.subjectGlycyrrhiza Glabra
dc.titleEffect of glabridin on microvascular permeability of plasma proteins induced by carrageenan
dc.typeArticle

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