New therapeutic system based on hydrogels for vaginal candidiasis management: Formulation-characterization andin vitroevaluation based on vaginal irritation and direct contact test

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dc.contributor.authorArpa, Muhammet Davut
dc.contributor.authorYoltaş, Ayşegül
dc.contributor.authorOnay Tarlan, Ecehan
dc.contributor.authorŞahin Şenyüz, Cemre
dc.contributor.authorSipahi, Hande
dc.contributor.authorAydın, Ahmet
dc.contributor.authorÜstündağ Okur, Neslihan
dc.date.accessioned2020-12-01T07:59:12Z
dc.date.available2020-12-01T07:59:12Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractThe objective of the present research was to examine the possible usage of terbinafine loaded hydrogels for vaginal application as part of vaginal candidiasis treatment. Vaginal candidiasis belongs to the most frequent gynecological disorders. Various antifungal drugs are used for its treatment, with Terbinafine being one of them. In this study, new gel formulations were prepared for Terbinafine vaginal delivery. Natural polymers such as chitosan, sodium carboxymethylcellulose, and Carbopol were used for the development of Terbinafine vaginal gels. The developed gels were examined for their viscosity and spreadability, pH and mechanical properties. The most optimal formulations were further evaluated for theirin vitrorelease behavior and antifungal activities. In further, the cytotoxicity and irritation inducing capacity of optimum gel formulations were evaluated.In vitrodrug release studies demonstrated that terbinafine release was prolonged whereas anti-candida activity in several species showed the superiority of the gels compared to the marketed product. G-5 and G-8 gels did not cause lysis, hemorrhage and coagulation, therefore, classified as non-irritant. The optimal formulations were also studied for their stability, demonstrating that they were stable for 3 months.
dc.identifier.citationArpa, M. D., Yoltaş, A., Onay Tarlan, E., Şahin Şenyüz, C., Sipahi, H., Aydın, A. ... Üstündağ Okur, N. (2020). New therapeutic system based on hydrogels for vaginal candidiasis management: Formulation-characterization andin vitroevaluation based on vaginal irritation and direct contact test. Pharmaceutical Development and Technology, 25(10), 1238-1248. https://dx.doi.org/10.1080/10837450.2020.1809457
dc.identifier.doi10.1080/10837450.2020.1809457
dc.identifier.endpage1248
dc.identifier.issn1083-7450
dc.identifier.issn1097-9867
dc.identifier.issue10
dc.identifier.scopusqualityN/A
dc.identifier.startpage1238
dc.identifier.urihttps://dx.doi.org/10.1080/10837450.2020.1809457
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6065
dc.identifier.volume25
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofPharmaceutical Development and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectVaginal Delivery
dc.subjectTerbinafine
dc.subjectHydrogels
dc.subjectHET-CAM
dc.subjectChitosan
dc.subjectCarbopol
dc.subjectSodium Carboxymethylcellulose
dc.titleNew therapeutic system based on hydrogels for vaginal candidiasis management: Formulation-characterization andin vitroevaluation based on vaginal irritation and direct contact test
dc.typeArticle

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