Enzyme-based antiviral potential of cinnamomum verum j. presl. essential oil and ıts major component (e)-cinnamaldehyde
| dc.authorid | 0000-0002-3412-0807 | |
| dc.authorid | 0000-0003-1896-2729 | |
| dc.contributor.author | Karadağ, Ayşe Esra | |
| dc.contributor.author | Biltekin, Sevde Nur | |
| dc.contributor.author | Ghani, Usman | |
| dc.contributor.author | Demirci, Betül | |
| dc.contributor.author | Demirci, Fatih | |
| dc.date.accessioned | 2024-05-03T12:25:44Z | |
| dc.date.available | 2024-05-03T12:25:44Z | |
| dc.date.issued | 2024 | |
| dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı | |
| dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı | |
| dc.description.abstract | In the present study, Cinnamomum verum J. Presl. bark essential oil and its main component cinnamaldehyde was evaluated in vitro for neuraminidase (NA), transmembrane serine protease (TMPRSS2), and angiotensin converting enzyme 2 (ACE2) inhibitory activities. The chemical composition of C. verum essential oil was confirmed by both gas chromatography-mass spectrometry (GC/MS), and gas chromatography-flame ionization detection (GC-FID), where 75.9% (E)-cinnamaldehyde was the major component. The ACE2, NA, and TMPRSS2 enzyme inhibitions of C. verum bark essential oil at 20 ?g/mL concentration, and (E)-cinnamaldehyde (5 ?g/mL) were calculated and compared in the range of 54.2-89.9%. Molecular docking results supported that (E)-cinnam-aldehyde was specific to ACE2 with 89.9% inhibition. Our findings suggest further in vivo studies to confirm the effective and safe use of the essential oil as well as the (E)-cinnamaldehyde. | |
| dc.description.sponsorship | Research project of the Anadolu University Scientific Research Projects Commission | en_US |
| dc.identifier.citation | Karadağ, A. E., Biltekin, S. N., Ghani, U., Demirci, B. ve Demirci, F. (2024). Enzyme-based antiviral potential of cinnamomum verum j. presl. essential oil and ıts major component (e)-cinnamaldehyde. ACS Omega, 9(12), 14118-14122. http://dx.doi.org/10.1021/acsomega.3c09595 | |
| dc.identifier.doi | 10.1021/acsomega.3c09595 | |
| dc.identifier.endpage | 14122 | |
| dc.identifier.issn | 2470-1343 | |
| dc.identifier.issue | 12 | |
| dc.identifier.pmid | 38559956 | |
| dc.identifier.scopus | 2-s2.0-85187661507 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | 14118 | |
| dc.identifier.uri | http://dx.doi.org/10.1021/acsomega.3c09595 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/12431 | |
| dc.identifier.volume | 9 | |
| dc.identifier.wos | 001184790200001 | en_US |
| dc.identifier.wosquality | Q2 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.institutionauthor | Karadağ, Ayşe Esra | |
| dc.institutionauthor | Biltekin, Sevde Nur | |
| dc.language.iso | en | |
| dc.relation.ec | info:eu-repo/grantAgreement/EC/FP7/2005S058 | |
| dc.relation.ispartof | ACS Omega | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | Attribution 4.0 International | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | ACE2 | |
| dc.subject | BINDING | |
| dc.title | Enzyme-based antiviral potential of cinnamomum verum j. presl. essential oil and ıts major component (e)-cinnamaldehyde | |
| dc.type | Article |
