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Öğe Bridging the gap: a narrative review of osteoporosis disability, adipokines, and the role of AI in postmenopausal women(2024) Tariq, Saba; Jabbar, Sohail; Ahmad, Awais; Tariq, SundusOsteoporosis is a global health concern characterized by reduced bone density and compromised bone quality, resulting in an increased risk of fractures, particularly in postmenopausal women. The assessment of bone mineral density (BMD) plays a pivotal role in diagnosing osteoporosis, as it accounts for approximately 70% of overall bone strength. The World Health Organization (WHO) has endorsed BMD measurement as a reliable method for diagnosing this condition. In Pakistan, the incidence of bone fractures is on the rise, largely attributable to an aging population and a range of contributing factors. Understanding the global and local prevalence of osteoporosis, its impact on morbidity and mortality, and the contributing factors is vital for developing effective preventive and therapeutic strategies. The role of adipokines, including chemerin, vaspin, and omentin-1, in bone metabolism is an emerging area of investigation. These adipokines play diverse roles in physiology, ranging from inflammation and metabolic regulation to cardiovascular health. Understanding their potential impact on bone health is a topic of ongoing research. The intricate relationship between bone density, bone quality, and overall bone strength is central to understanding the diagnosis and management of osteoporosis. Current innovation in machine learning and predictive model can bring revolution in the field of bone health and osteoporosis. Early identification of people with osteoporosis or risk of fracture through machine learning can prevent disability and improve the quality of life.Öğe Bridging theory and practice: how adult learning theories shape interactive lectures(2024) Baig, Mukhtiar; Tariq, Saba; Tariq, Sundus...Öğe Centralized healthcare database for ensuring better healthcare: Are we lagging behind?(Professional Medical Publications, 2024) Tariq, Sundus; Tariq, Saba; Shoukat, Ahmad AdnanDatabase is an organized set of large information gathered and stored electronically to be retrieved whenever required. The systematically stored information can be accessed, analyzed, updated or moved to other databases as per the requirement. A centralized healthcare database (CHD) is a memory house of health data from a wider population, where information such as health records, financial data, billing and claims information and inventory use is not only stored systematically but can also be retrieved, analyzed, and integrated. The data can be assessed by the health care providers, researchers, policy makers, institutions and by the patients themselves.Öğe Data-driven medicine: The promise and potential of clinical decision support systems(University of Faisalabad, 2024) Tariq, Saba; Tariq, SundusPatient safety is one of the most important factors involved in any health care policy. The idea of evidence-based medicine has emerged as the dominant paradigm in clinical practice, influencing our current understanding of medicine. Clinical decisions are based on accumulated scientific information in order to provide the best possible care, enhance patient outcomes, and save expenses.Öğe Editorial: Osteoporosis and adipokines: the potential for future treatment(2024) Tariq, Saba; Tariq, Sundus; Baig, Mukhtiar; Valjevac, AminaOsteoporosis is a major health concern, particularly in older people. It is characterized by decreased bone density and a higher fracture risk. Globally, it affects 35.3% of women and 12.5% of men (1). Recent studies have concentrated on the role of adipokines in bone metabolism control and osteoporosis progression. Adipokines are signaling substances produced by adipose tissue. Leptin, resistin, chemerin, visfatin, and other proteins have been shown to alter bone metabolism, making them possible targets for future osteoporosis treatments (2–4).Öğe Examining the tapestry of mental health crises in low-& middle-income countries: An intercontinental analysis of the contributing factors and instructive approaches(University of Faisalabad, 2023) Mubarak, Naeem; Kanwal, Sabba; Rana, Fatima Rahman; Tariq, Saba; Tariq, Sundus; Elnaem, Mohamed Hassan; Khan, Asad MajeedIn recent decades, the intricate landscape of mental health challenges has become a focal point of global concern, with particular urgency in Low-and Middle-Income Countries (LMICs). This manuscript delves into the multidimensional tapestry of mental health issues prevalent in these regions, offering an intercontinental analysis that seeks to unravel the contributing factors and proposes strategies for improvement. Through a meticulous examination of diverse sociocultural, economic, and healthcare-related variables, this study aims to provide a comprehensive understandingof the complex dynamics shaping mental health crises in LMICs. Through an intercontinental lens, our analysis aims to transcend geographical boundaries, examining the commonalities and distinctions inherent in the mental health landscapes of LMICs. This inquiry is driven by a dual commitment: to comprehensively understand the determinants of mental health challenges and to identify instructive approaches that can serve as foundations for targeted interventions. In navigating this intellectual terrain, our study not only strives to contribute to the academic discourse on global mental health but also aspires to inform policy and practice, fostering a nuanced understanding of mental health dynamics and cultivating evidence-based strategies to ameliorate the burden faced by individuals in LMICs. By synthesizing current research, empirical data, and theoretical frameworks, our exploration not only illuminates the challenges but also endeavors to identify instructive approaches for mitigating the impact of mental health issues in resource-constrained settings. The confluence of factors influencing mental health in LMICs demands an interdisciplinary lens, and this manuscript endeavors to navigate this intricate terrain with rigor and precision.. This article exposes the significant gap in mental health services, attributing this disparity to limited public funding, insufficient allocation for children and adolescents, and an inadequate distribution of funds in mental health infrastructure. The scarcity of mental health workers, particularly in primary healthcare settings, further exacerbates the problem. The contributing factors to mental health crises in LMICs include ineffective legislation, leadership, and national health policies, as well as cultural beliefs and stereotypes. The lack of a mental health information system further hampers meaningful progress in these regions. There is a need for a comprehensive mental health system that considers cultural, social, and economic factors unique to LMICs. To address the challenges faced by LMICs, the article suggests strategies, including legislative reforms, policy development, public education to reduce stigma, and promotion of evidence-based interventions. By drawing on existing principles and considerations, the authors provide a specific system of mental health services grounded in community-based care and "mental health-in-all-policies" approach which advocates for rational investment allocations, considering social determinants, prevalence data, and the humane treatment of individuals with mental health issues in these regions.Öğe Osteoprotegerin genetic polymorphisms and their influence on therapeutic response to ibandronate in postmenopausal osteoporotic females(Public Library of Science, 2023) Tariq, Saba; Tariq, Sundus; Abualhamael, Shahad Abduljalil; Baig, Mukhtiar; Malik, Ahmad Azam; Shahzad, MuhammadObjectivesThe present study investigated osteoprotegerin (OPG) genetic polymorphisms and their influence on the therapeutic response to ibandronate in postmenopausal osteoporotic females.MethodsThis case-control study included 135 postmenopausal females (89 osteoporotic females and 46 non-osteoporotic females). Each osteoporotic patient received a monthly 150 mg ibandronate tablet for six months, and blood samples were taken before and after treatment. Bone mineral density (BMD) was measured using DEXA Scan. Three SNPs (A163G, T245G, and G1181C) of the OPG gene were selected for analysis.ResultsSerum OPG levels were significantly lower in osteoporotic subjects than in the control group. The percentage changes in OPG levels in the osteoporotic group before and after treatment with ibandronate were significant (p < .001). After six months of therapy with ibandronate, the percentage changes in OPG levels with AA, TT, TC, GC, and GG genotypes were significant. Following six months of ibandronate treatment, the AA genotype of rs3134069, TT, TC genotypes of rs3102735, GG, and GC genotypes of rs2073618 SNP showed a significant increase in OPG levels. Age, BMI, and GC polymorphism (rs2073618 (G/C) G1181C) were inversely associated with low BMD. Adjusted odds ratios (OR) showed that BMI, GC, GG polymorphism (rs2073618 (G/C) G1181C) and TC polymorphism (rs3102735 (T/C) A163G) were inversely associated with low BMD.ConclusionThe inverse association of rs2073618 and rs3102735 with low BMD indicates the protective role of these SNPs in our population. More research is needed to replicate these results in another cohort and to determine the molecular processes by which such SNPs may influence BMD.Öğe Telehealth: A bridge divided? Bridging the digital divide for equitable healthcare access(2024) Tariq, Sundus; Zaqout, Abdalrahman; Tariq, SabaTelehealth, which is the use of telecommunications technology in health care delivery according to the Health Resources and Services Administration, is also a subset of e-health. Telehealth, which provides medical assistance to remote patients, is performed through a variety of different actions and services which include interactions between patients and healthcare providers happening through the phone, e-mails, video calls, the web, remote devices, as well as short message services (SMS).Öğe The role of digital health solutions in modern medicine(2024) Tariq, Saba; Tariq, Sundus[Abstract Not Available]
