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Öğe A new hope in the treatment of steroid-refractory graft versus host disease (Sr-GVHD) after allogeneic hematopoetic stem cell transplantation (AHSCT): Ruxolitinib(Springer Nature, 2020) İlhan, Osman; Cengiz Seval, Güldane; Civriz Bozdağ, Sinem; Deveci, Burak; Pehlivan, Mustafa; Kaynar, Leylagül; Yavaşoğlu, İrfan; Beköz, Hüseyin Saffet; Yönal Hindilerden, İpek; Yeğin, Zeynep Arzu; Dağdaş, Simten; Avşar, Ayşe; Özkan, Atilla Hasan; Fırat Tuğlular, Tülin; Göker, Hakan; Gülbaş, Zafer[Abstract Not Available]Öğe Association study of CFH Y402H functional variant with genetic susceptibility to nicotine dependence and schizophrenia in Turkish population(American Society for Cell Biology, 2018) Sever, Ülgen; Nursal, Ayşe Feyda; Çetinay Aydın, Pınar; Uysal, Mehmet Ali; Özdilli, Kürşat; Pehlivan, Mustafa; Aydın, Nur Gökçe; Pehlivan, Sacide[Abstract Not Available]Öğe DNA repair genes and chronic myeloid leukemia: ERCC2 (751), XRCC1 (399), XRCC4-Intron 3, XRCC4 (-1394) gene polymorphisms(Mattioli 1885, 2021) Özdilli, Kürşat; Pehlivan, Mustafa; Serin, İstemi; Oğuz Savran, Fatma; Tomatır, Ayşe Gaye; Pehlivan, SacideTo the editor. Chronic myeloid leukemia (CML), which is characterized by the overproduction of mature cells in the granulocytic series, is included in the group of chronic myeloproliferative neoplasms.1 It is the first disease ascertained as due to a specific chromosomal anomaly emerging from a reciprocal translocation between chromosomes 9 and 22. A chimeric gene denominated as the Philadelphia (Ph) chromosome is the product of the fusion of the Abelson oncogene (ABL) from chromosome 9q34 with the breakpoint cluster region (BCR) on chromosome 22q11.2, t (9;22)(q34;q11.2).Öğe Do UCP2, IL-17, mi196a2, and NR3C1 gene variants contribute to the risk of microtia? A preliminary study in Turkish population(Elsevier Science Bv, 2018) Özdilli, Kürşat; Bekerecioğlu, Mehmet; Nursal, Ayşe Feyda; Pehlivan, Mustafa; Sever, Ülgen; Büyükgüral, Berker; Pehlivan, SacideMicrotia is a congenital malformation of variable severity of theexternal and middle ear. Although many genetic and environmen-tal factors are investigated the etiopathogenesis of microtia, it isstill uncertain. We performed case–control analysis to assess theeffect of UCP2?866 G/A, IL-17?7488 A/G, miR196a2 T/C, NR3C1Bcl1 variants on the risk of microtia. This study includes 18 microtiapatients and 70 healthy controls. The functional variants of UCP2,IL-17, miR196a2, andNR3C1genes were evaluated using PCR-RFLPmethod. The frequencies of the alleles and genotypes in groupswere compared by the 2test A significant difference was foundbetween the control group and the patients as for genotype andallele frequencies of NR3C1 Bcl1 variant. No significant differencewas found in the distribution of genotypes and alleles frequen-cies between patients and healthy controls for UCP2, IL-17, andmiR196a2 variants (p> 0.05). To our knowledge, this is the firststudy to evaluate relationship between these gene variants andmicrotia risk in a Turkish cohort. Our results suggest that theNR3C1Bcl1 variant might reflect the risk of microtia in a Turkish popula-tion. Further studies in larger populations are required to achievea definitive conclusion.Öğe Effect of cytokine genes in the pathogenesis and on the clinical parameters for the treatment of multiple myeloma(Taylor & Franis Ltd, 2017) Haydaroğlu, Handan; Oğuzkan Balcı, Sibel; Pehlivan, Sacide; Özdilli, Kürşat; Gündoğan, Ersin; Okan, Vahap; Nursal, Ayşe Feyda; Pehlivan, MustafaIn this study, we aimed to explore the association among gene variants of five cytokines, tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta-1 (TGF-beta 1), interferon gamma (IFN-gamma), interleukin-6 (IL-6), and interleukin-10 (IL-10), and clinical parameters and prognosis in patients with multiple myeloma (MM) treated with novel therapeutic drugs in Turkish population for the first time except TNF-alpha. We analyzed five cytokine genes in 113 cases with MM and 113 healthy controls. Cytokine genotyping was performed by the polymerase chain reaction-sequence-specific primer method (PCR-SSP). AG genotype associated with high expression in TNF-alpha gene (-308) variant was found to be significantly higher (p = 0.019), and GG genotype associated with low expression in TNF-alpha gene (-308) variant was significantly lower in MM group as compared with controls (p = 0.012). IFN-gamma (+874) variant TT genotype was increased (p = 0.037), and AA genotype was decreased (p = 0.002) in MM group in contrast to controls. IFN-gamma (+874) T allele was higher inMMpatients compared with controls (OR = 1.985, p = 0.000), while A allele was significantly lower (OR = 0.5037, p = 0.0005). Multivariate analysis revealed that factors associated with 5-year overall survival (OS) were only IPI III (RR = 1.630, p = 0.018) and thrombocytopenia (RR = 2.207, Cox p = 0.021), while 5-year event-free survival (EFS) was associated with IPI III (RR = 1.524, p = 0.022), thrombocytopenia (RR = 2.902, p = 0.002), APSCT treatment (RR = 1.729, p = 0.035), and female gender (RR = 0.435, p = 0.002) with negative prognostic values. Our results suggested that TNF-alpha gene (-308) AG genotype and IFN-gamma (+874) TT genotype and T allele may have a role on MM, while other cytokines were not associated with the risk of MM.Öğe Evaluation of gene-gene interaction between the interleukin (IL)-2 and IL-2RA gene polymorphisms in schizophrenia patients in the Turkish Population(2024) Özdilli, Kürşat; Aytaç, Hasan Mervan; Tuncel, Fatima Ceren; Oyacı, Yasemin; Pehlivan, Mustafa; Pehlivan, SacideOBJECTIVES: To evaluate the genetic polymorphisms in IL-2 and IL-2RA genes in schizophrenia (SCZ) patients by comparing them with healthy controls. METHODS: A sample of 127 patients with SCZ and 100 healthy volunteers were included in the case-control study. These individuals were consecutively selected from the Malazgirt State Hospital Psychiatry Outpatient Clinic in Mus, Turkey, over the three months from October 2020 to December 2020. The Structured Clinical Interview for DSM-5 Disorders, Clinician Version (SCID-5-CV) was used to confirm the diagnosis according to the DSM-5 criteria. In addition, polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine gene polymorphisms from DNA material. RESULTS: Our findings indicated significant differences in the IL-2 genotype and allele frequencies between SCZ patients and the healthy control group. Specifically, the frequency of the homozygous GG genotype was notably higher in SCZ patients compared to the control group. Conversely, when comparing the IL-2RA genotype and allele frequencies of SCZ patients with the control group, no statistically significant differences were observed between the 2 groups. When compared to individuals with other genotypes, interaction analysis indicated that carriers of the GG/AG (IL-2/IL-2RA) genotype demonstrated a significantly increased risk of SCZ. CONCLUSION: In light of the analyses, our study indicates that while the IL-2 genotype polymorphism may be considered a risk factor for developing SCZ, the IL-2RA variant was not associated with SCZ among Turkish patients.Öğe Gene polymorphisms and febrile neutropenia in acute leukemia-no association with IL-4, CCR-5, IL-1RA, but the MBL-2, ACE, and TLR-4 are associated with the disease in Turkish patients: A preliminary study(Mary Ann Liebert, Inc., 2014) Pehlivan, Mustafa; Haydaroğlu Şahin, Handan; Özdilli, Kürşat; Onay, Hüseyin; Özcan, Ali; Özkinay, Ferda; Pehlivan, SacideAims: The aim of this study was to investigate the mannose-binding lectin 2 (MBL-2), interleukin (IL)-4, Toll-like receptor 4 (TLR-4), angiotensin converting enzyme (ACE), chemokine receptor 5 (CCR-5), and IL-1 receptor antagonist (RA) gene polymorphisms (GPs) in acute leukemias (ALs) and to evaluate their roles in febrile neutropenia (FN) resulting from chemotherapy. Methods: The study included 60 AL patients hospitalized between the period of July 2001 and August 2006. Polymorphisms for the genes ACE(I/D), CCR-5, IL-1RA, MBL-2, TLR-4, and IL-4 were typed by polymerase chain reaction (PCR) and/or PCR-restriction fragment length polymerase. Genotype frequencies for these genes were compared in the patient and control groups. The relationships between the genotypes and the body distribution of infections, pathogens, the duration of neutropenia, and febrile episodes in AL patients were evaluated. Results: No significant differences in either the genotype distribution or the allelic frequencies of TLR-4, IL-4, CCR-5, IL-1RN GPs were observed between patients and healthy controls. The AB/BB genotype (53.3%) in the MBL-2 gene was found to be significantly higher in the AL patients compared with control groups. There were correlations between the presence of MBL-2, TLR-4, and ACE polymorphisms and clinical parameters due to FN. Overall, bacteremia was more common in MBL BB and ACE DD. Gram-positive bacteremia was more common in ACE for ID versus DD genotype. Gram-negative bacteremia was more common for both the MBL-2 AB/BB genotype and TLR-4 AG genotype. Median durations of febrile episodes were significantly shorter in ACE DD and MBL AB/BB. Conclusion: Although TLR-4, ACE, and MBL-2 GPs have been extensively investigated in different clinical pictures, this is the first study to evaluate the role of these polymorphisms in the genetic etiopathogenesis of FN in patients with ALs. As a conclusion, TLR-4, ACE, and MBL-2 genes might play roles in the genetic etiopathogenesis of FN in patients with ALs.Öğe Is interleukin 17F (7488 A/G) responsible for the pathogenesis of breast and gastrointestinal cancers in Turkish patients(American Society for Cell Biology, 2018) Özdilli, Kürşat; Günaldı, Meral; Pehlivan, Mustafa; Nursal, Ayşe Feyda; Işıksaçan, Nilgün; Pehlivan, Sacide[Abstract Not Available]Öğe Mi196a2 T/C variant as possible predisposal factor for ankylosing spondylitis in a Turkish population(Elsevier Science Bv, 2018) Pehlivan, Sacide; Gürsoy, Savaş; Nursal, Ayşe Feyda; Akaltun, Mazlum Serdar; Özdilli, Kürşat; Pehlivan, MustafaAnkylosing spondylitis (AS) is a chronic inflammatory disorder. Micro RNAs (miRNAs), small noncoding RNA molecules, can function as either oncogenes or tumor suppressor genes. Altered miRNA expression has been implicated in the pathogenesis of several diseases. Therefore, we aimed to explore the effects of miR-196a2 T/C (rs11614913) variant profile on susceptibility to AS in a Turkish population. Blood samples were collected from 78 AS patients and 79 controls.Öğe Post-authorization safety of lenalidomide plus dexamethasone in patients with relapsed/refractory multiple myeloma in Turkey(CIG Media Group, 2022) Fıratlı Tuğlular, Ayşe Tülin; Pehlivan, Mustafa; Sönmez, Mehmet; Kabukçu Hacıoğlu, Sibel; Saydam, Güray; Ayyıldız, Orhan; Kaynar, Leylagül; Demirkan, Fatih; Beksaç, Meral[Abstract Not Available]Öğe Prognostic importance of single-nucleotide polymorphisms in IL-6, IL-10, TGF-beta 1, IFN-gamma, and TNF-alpha genes in chronic phase chronic myeloid leukemia(Mary Ann Liebert, Inc, 2014) Pehlivan, Mustafa; Haydaroğlu Şahin, Handan; Pehlivan, Sacide; Özdilli, Kürşat; Kaynar, Leylagül; Savran Oğuz, Fatma; Sever, Tuğçe; Yılmaz, Mehmet; Eser, Bülent; Duvarcı Öğret, Yeliz; Kis, Cem; Okan, Vahap; Çetin, Mustafa; Carin, MahmutThe aim of this study was to explore the association between polymorphisms of five cytokine genes and clinical parameters in patients with Philadelphia-positive (Ph+) chronic myeloid leukemia (CML) treated with imatinib. We analyzed five cytokine genes (interleukin [IL]-6, IL-10, gamma interferon [IFN-gamma], transforming growth factor beta-1 [TGF-beta 1], and tumor necrosis factor-alpha [TNF-alpha]) in 60 cases with Ph+ CML and 74 healthy controls. Cytokine genotyping was performed by the polymerase chain reaction-sequence-specific primer. All data were analyzed using the de Finetti program and SPSS version 14.0 for Windows. No significant differences were detected between the CML group and healthy controls with respect to the distributions and numbers of genotypes and alleles in TNF-alpha, TGF-beta 1, IL-10, and IFN-gamma. However, the GG genotype associated with high expression in IL-6 was found to be significantly more frequent in CML as compared to controls (p = 0.010). The median follow-up time was 49.3 months (range 6.1-168.4) and the median duration of imatinib treatment was 39.5 months (range 5.2-103.4) for these patients. On multivariateanalysis, only IL-10 GCC/GCC highly produced haplotypes were significantly associated with a shorter event-free survival. The relationship between cytokine genotypes/haplotypes and clinical parameters in CML has not been investigated before. Our results suggest that IL-10 may be a useful marker for CML prognosis and theGG genotype of the IL-6 gene may be associated with susceptibility.Öğe The mir-196a2t/c variant as a possible predisposing factor for ankylosing spondylitis in a Turkish population2(Istanbul University Publisher, 2020) Pehlivan, Sacide; Gürsoy, Savaş; Nursal, Ayşe Feyda; Akaltun, Mazlum Serdar; Özdilli, Kürşat; Pehlivan, MustafaObjective: Ankylosing spondylitis (AS) is a chronic inflammatory disorder. MicroRNAs (miRNAs) can function as either oncogenes or tumor suppressor genes. Altered miRNA expression has been implicated in the pathogenesis of several diseases. Therefore, we aimed to explore the effects of miR-196a2T/C (rs11614913) variant profile on susceptibility to AS in a Turkish population.Materials and Methods: Blood samples were collected from 78 AS patients and 79 healthy controls. miR-196a2T/C variant was genotyped by PCR-RFLP. Odds ratio (OR) with 95% confidence interval (95%CI) were calculated using the chi(2) test.Results: The frequency of T/C and T/T genotypes of the miR196a2T/C were higher in AS patients compared to healthy controls (p=0.034 and p=0.028, respectively). The subjects carrying the miR-196a2T/C variant T/T genotype showed a 2.542-fold increased AS risk than the control group. However, no difference was observed in the allele frequencies of miR-196a2T/C between AS patients and the controls. It was found that C/C genotype of miR-196a2T/C variant was more frequent in AS patients with enthesitis than AS patients without enthesitis (p=0.042).Conclusion: The miR-196a2T/C variant represents a genetic risk factor for increased susceptibility to AS and is associated with enthesitis in the Turkish population.Öğe Tumor necrosis factor-alpha (TNF-alpha)-238 G/A polymorphism is associated with the treatment resistance and attempted suicide in schizophrenia(Taylor & Francis Ltd, 2022) Aytaç, Hasan Mervan; Özdilli, Kürşat; Tuncel, Fatıma Ceren; Pehlivan, Mustafa; Pehlivan, SacideAbnormality of the immune system may play an important role in the pathogenesis of schizophrenia (SCZ). We aim to investigate the relationship between clinical features of SCZ and tumor necrosis factor-alpha (TNF-?) -238 G/A, -308 G/A polymorphisms in SCZ patients by comparing genotype distributions of TNF-? gene polymorphisms between patients and healthy controls. A sample of 113 patients with SCZ and 104 healthy volunteers was included in the study. SCID-I was used to confirming the diagnosis according to DSM-IV-TR criteria. We evaluated the patients with some scales and data forms in terms of clinical features, symptom severity, level of insight, suicidal behavior, and treatment response. PCR-RFLP was used to determine TNF-? gene polymorphisms from DNA material. The distributions of TNF-? - 238 G/A and TNF-? - 308 G/A polymorphisms of the patients diagnosed with SCZ were not significantly different from the control group. There was a significant difference in the TNF-? - 238 G/A genotype distributions between treatment-resistant and treatment-responsive SCZ patients. Again, the distributions of TNF-? - 238 G/A genotype of attempted suicide patients in SCZ were significantly different from the non-attempted suicide of SCZ patients. Whereas TNF-? - 238 G/A and -308 G/A polymorphisms were not associated with SCZ, TNF-? - 238 G/A polymorphism may be related to treatment resistance and attempted suicide in SCZ patients in the Turkish population.
