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    Mi196a2 T/C variant as possible predisposal factor for ankylosing spondylitis in a Turkish population
    (Elsevier Science Bv, 2018) Pehlivan, Sacide; Gürsoy, Savaş; Nursal, Ayşe Feyda; Akaltun, Mazlum Serdar; Özdilli, Kürşat; Pehlivan, Mustafa
    Ankylosing spondylitis (AS) is a chronic inflammatory disorder. Micro RNAs (miRNAs), small noncoding RNA molecules, can function as either oncogenes or tumor suppressor genes. Altered miRNA expression has been implicated in the pathogenesis of several diseases. Therefore, we aimed to explore the effects of miR-196a2 T/C (rs11614913) variant profile on susceptibility to AS in a Turkish population. Blood samples were collected from 78 AS patients and 79 controls.
  • Küçük Resim
    Öğe
    The mir-196a2t/c variant as a possible predisposing factor for ankylosing spondylitis in a Turkish population2
    (Istanbul University Publisher, 2020) Pehlivan, Sacide; Gürsoy, Savaş; Nursal, Ayşe Feyda; Akaltun, Mazlum Serdar; Özdilli, Kürşat; Pehlivan, Mustafa
    Objective: Ankylosing spondylitis (AS) is a chronic inflammatory disorder. MicroRNAs (miRNAs) can function as either oncogenes or tumor suppressor genes. Altered miRNA expression has been implicated in the pathogenesis of several diseases. Therefore, we aimed to explore the effects of miR-196a2T/C (rs11614913) variant profile on susceptibility to AS in a Turkish population.Materials and Methods: Blood samples were collected from 78 AS patients and 79 healthy controls. miR-196a2T/C variant was genotyped by PCR-RFLP. Odds ratio (OR) with 95% confidence interval (95%CI) were calculated using the chi(2) test.Results: The frequency of T/C and T/T genotypes of the miR196a2T/C were higher in AS patients compared to healthy controls (p=0.034 and p=0.028, respectively). The subjects carrying the miR-196a2T/C variant T/T genotype showed a 2.542-fold increased AS risk than the control group. However, no difference was observed in the allele frequencies of miR-196a2T/C between AS patients and the controls. It was found that C/C genotype of miR-196a2T/C variant was more frequent in AS patients with enthesitis than AS patients without enthesitis (p=0.042).Conclusion: The miR-196a2T/C variant represents a genetic risk factor for increased susceptibility to AS and is associated with enthesitis in the Turkish population.