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dc.contributor.authorKılıç, Şeyma
dc.contributor.authorAslan, Asile Seval
dc.contributor.authorHelvacı Yılmaz, Nesrin
dc.date.accessioned2022-09-30T11:34:25Z
dc.date.available2022-09-30T11:34:25Z
dc.date.issued2022en_US
dc.identifier.citationKılıç, Ş., Aslan, A. S. ve Helvacı Yılmaz, N. (2022). Parkinson’s disease - Its pathophysiology to etiology. The Handbook of Neuromodulation (2 Volume Set): Volme 1 içinde (47-62. ss.). Nova Science Publishers, Inc.en_US
dc.identifier.isbn9781685077891
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9779
dc.description.abstractThe symptoms of Parkinson’s disease are well-known, but there are still little known about pathophysiology to etiology. Alpha-synuclein and Lewy body accumulation in neurons of substansia nigra, mitochondrial dysfunction and oxidative stress, neuro-inflammation caused by microglia, glutamate excitotoxicity and gut microbiota are the possible pathogenetic factors. The motor symptoms, dopamine depletion due to alpha-synuclein neurotoxicity leads to bradykinesia and rigidity while dysfunction of the cerebellumthalamo- cortical circuit is the underlying mechanism for tremor. Age, pesticides, head trauma, malignant melanoma are the major environmental risk factors while smoking, caffeine, Mediterranean diet and exercise are the main protective factors. By avoiding the risk factors and providing disease-modifying therapies, Parkinson’s Disease may become a curable disease.en_US
dc.language.isoengen_US
dc.publisherNova Science Publishers, Inc.en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectParkinson’s Diseaseen_US
dc.subjectPathophysiologyen_US
dc.subjectEtiologyen_US
dc.titleParkinson’s disease - Its pathophysiology to etiologyen_US
dc.typebookParten_US
dc.relation.ispartofThe Handbook of Neuromodulation (2 Volume Set): Volme 1en_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.authorid0000-0002-2761-0031en_US
dc.authorid0000-0001-7566-1063en_US
dc.identifier.volume1en_US
dc.identifier.startpage47en_US
dc.identifier.endpage62en_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.institutionauthorKılıç, Şeyma
dc.institutionauthorAslan, Asile Seval
dc.institutionauthorHelvacı Yılmaz, Nesrin
dc.identifier.scopus2-s2.0-85137884786en_US


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