dc.contributor.author | Saltoğlu, Neşe | |
dc.contributor.author | Dinç, Harika Öykü | |
dc.contributor.author | Balkan, İlker İnanç | |
dc.contributor.author | Can, Günay | |
dc.contributor.author | Özbey, Doğukan | |
dc.contributor.author | Beytur, Ayşe Nur | |
dc.contributor.author | Keskin, Elif | |
dc.contributor.author | Budak, Beyhan | |
dc.contributor.author | Aydoğan, Okan | |
dc.contributor.author | Mete, Bilgül | |
dc.contributor.author | Karaali, Rıdvan | |
dc.contributor.author | Ergin, Sevgi | |
dc.date.accessioned | 2022-08-08T07:10:53Z | |
dc.date.available | 2022-08-08T07:10:53Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Saltoğlu, N., Dinç, H. Ö., Balkan, İ. İ., Can, G., Özbey, D., Beytur, A. N. ... Ergin, S. (2022). Heterologous booster COVID-19 vaccination elicited potent immune responses in HCWs. Diagnostic Microbiology and Infectious Disease, 104(2). https://doi.org/10.1016/j.diagmicrobio.2022.115758 | en_US |
dc.identifier.issn | 0732-8893 | |
dc.identifier.uri | https://doi.org/10.1016/j.diagmicrobio.2022.115758 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/9636 | |
dc.description.abstract | The objective of our study was to evaluate the antibody responses of health care workers (HCWs) who were vaccinated with booster dose BNT162b2 6 months after 2 doses of the CoronoVac vaccine. The study included 318 HCWs vaccinated with inactive CoronaVac SARS-CoV-2 vaccine in 2 doses. Anti-spike/RBD IgG levels were measured immediately before and 1 month after the booster dose. In the sixth month after CoronaVac vaccination, the median of antibody levels of 1212.02 AU/ML, while it was 9283 AU/mL after BNT162b2 vaccination. IgG antibody titers of over 1050 AU/mL (which is equivalent to 1:80 dilution in the plaque reduction neutralization test) were detected in HCWs 15.09% and 97.8%, respectively. Our results showed that antibody titers increased 8-fold after the booster dose. We believe that the administration of the mRNA vaccine as a booster dose can provide more effective protection against COVID-19 infection, especially in individuals with risk factors. | en_US |
dc.description.sponsorship | IU-Cerrahpaşa Scientific Research Projects Unit | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Inc. | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Antibody | en_US |
dc.subject | BNT162b2 | en_US |
dc.subject | CoronaVac | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Vaccine | en_US |
dc.title | Heterologous booster COVID-19 vaccination elicited potent immune responses in HCWs | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Diagnostic Microbiology and Infectious Disease | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-7275-8724 | en_US |
dc.identifier.volume | 104 | en_US |
dc.identifier.issue | 2 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.diagmicrobio.2022.115758 | en_US |
dc.institutionauthor | Aydoğan, Okan | |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.wos | 000834101500001 | en_US |
dc.identifier.scopus | 2-s2.0-85134734769 | en_US |
dc.identifier.pmid | 35878507 | en_US |
dc.identifier.scopusquality | Q2 | en_US |