Heterologous booster COVID-19 vaccination elicited potent immune responses in HCWs

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2022Author
Saltoğlu, NeşeDinç, Harika Öykü
Balkan, İlker İnanç
Can, Günay
Özbey, Doğukan
Beytur, Ayşe Nur
Keskin, Elif
Budak, Beyhan
Aydoğan, Okan
Mete, Bilgül
Karaali, Rıdvan
Ergin, Sevgi
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Saltoğlu, N., Dinç, H. Ö., Balkan, İ. İ., Can, G., Özbey, D., Beytur, A. N. ... Ergin, S. (2022). Heterologous booster COVID-19 vaccination elicited potent immune responses in HCWs. Diagnostic Microbiology and Infectious Disease, 104(2). https://doi.org/10.1016/j.diagmicrobio.2022.115758Abstract
The objective of our study was to evaluate the antibody responses of health care workers (HCWs) who were vaccinated with booster dose BNT162b2 6 months after 2 doses of the CoronoVac vaccine. The study included 318 HCWs vaccinated with inactive CoronaVac SARS-CoV-2 vaccine in 2 doses. Anti-spike/RBD IgG levels were measured immediately before and 1 month after the booster dose. In the sixth month after CoronaVac vaccination, the median of antibody levels of 1212.02 AU/ML, while it was 9283 AU/mL after BNT162b2 vaccination. IgG antibody titers of over 1050 AU/mL (which is equivalent to 1:80 dilution in the plaque reduction neutralization test) were detected in HCWs 15.09% and 97.8%, respectively. Our results showed that antibody titers increased 8-fold after the booster dose. We believe that the administration of the mRNA vaccine as a booster dose can provide more effective protection against COVID-19 infection, especially in individuals with risk factors.
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Diagnostic Microbiology and Infectious DiseaseVolume
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