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dc.contributor.authorKandemir, Levent
dc.contributor.authorKarakuş, Sevgi
dc.contributor.authorÖzbaş, Suna
dc.contributor.authorRollas, Sevim
dc.contributor.authorAkbuğa, Julide
dc.date.accessioned2022-07-25T12:16:40Z
dc.date.available2022-07-25T12:16:40Z
dc.date.issued2022en_US
dc.identifier.citationKandemir, L., Karakuş, S., Özbaş, S., Rollas, S. ve Akbuğa, J. (2022). Synthesis, structure elucidation and cytotoxic activities of 2,5-disubstituted-1,3,4-thiadiazole and l,2,4-triazole-3-thione derivatives. Journal of Research in Pharmacy, 26(4), 941-953. http://doi.org/10.29228/jrp.192en_US
dc.identifier.issn2630-6344
dc.identifier.urihttp://doi.org/10.29228/jrp.192
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9605
dc.description.abstractIn this study, a series of 1,3,4-thiadiazole (1b-9b) and l,2,4-triazole-3-thione (1c-9c) derivatives were synthesized. The reaction proses was carried out with the cyclocondensation of suitable 1,4-disubstituted thiosemicarbazide derivatives (1a-9a). The structures of the synthesized compounds were confirmed by the data obtained from elemental analysis, HPLC, UV, IR,1H-NMR and MS spectra. All of the compounds were tested for their cytotoxic activities against L929 fibroblast cells by MTT method. It was determined that the tested compounds 1a-9a, 1b-9b and 1c-9c were not cytotoxic at the studied concentrations (5.0 µg/mL and 10.0 µg/mL) in L929 cell lines. Compounds 1a-c, 2a-c, 3a-c, 4a-c, 5a-c and 8a-c showed increased growth inhibition whereas compounds 6a-c, 7a-c and 9a-c showed decreased growth inhibition on L929 cell lines.en_US
dc.language.isoengen_US
dc.publisherMarmara Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcid Hydrazideen_US
dc.subjectCytotoxicityen_US
dc.subject1,3,4-Thiadiazoleen_US
dc.subject1,4-Disubstituted Thiosemicarbazideen_US
dc.subject1,2,4-Triazole-3- Thioneen_US
dc.titleSynthesis, structure elucidation and cytotoxic activities of 2,5-disubstituted-1,3,4-thiadiazole and l,2,4-triazole-3-thione derivativesen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-1693-9579en_US
dc.identifier.volume26en_US
dc.identifier.issue4en_US
dc.identifier.startpage941en_US
dc.identifier.endpage953en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.29228/jrp.192en_US
dc.institutionauthorAkbuğa, Julide
dc.identifier.wos000836312200022en_US
dc.identifier.scopus2-s2.0-85133904069en_US
dc.identifier.trdizinid535934en_US
dc.identifier.scopusqualityQ3en_US


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