dc.contributor.author | Karadağ, Ayşe Esra | |
dc.contributor.author | Biltekin, Sevde Nur | |
dc.contributor.author | Demirci, Betül | |
dc.contributor.author | Demirci, Fatih | |
dc.date.accessioned | 2022-06-06T10:01:04Z | |
dc.date.available | 2022-06-06T10:01:04Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Karadağ, A. E., Biltekin, S. N., Demirci, B. ve Demirci, F. (2022). In vitro ACE2 enzyme inhibitory activity evaluation of different salvia essential oils. Acta Pharmaceutica Sciencia, 60(2), 117-124. https://doi.org/10.23893/1307-2080.APS.6008 | en_US |
dc.identifier.issn | 1307-2080 | |
dc.identifier.uri | https://doi.org/10.23893/1307-2080.APS.6008 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/9508 | |
dc.description.abstract | In this present study, commertially available Salvia triloba L., S.officinalis L., and S. sclarea L. essential oils were evaluated for their in vitro angiotensin converting enzyme 2 (ACE2) inhibitory activity. The Salvia essential oils compositions were confirmed both by GC-FID and GC/MS. Main components of the S. triloba essential oil was characterized as 1,8-cineole (22.8%), camphor (17.2%), α-thujone (15.2 %), β-caryophyllene (11.4 %), and α-humulene (3%). Major constiutents were identified as α-thujone (28.5 %), camphor (20.6 %), 1,8-cineole (10.9%), α-humulene (5%), and camphene (4.9 %) in S. officinalis essential oil. Whereas, linalylacetate (56.8 %), linalool (21.1%), α-terpineol (6.1%), geraniol (5%), and β-caryophyllene (3.4%) were the major components of S. sclarea essential oil. The essential oils were evaluated using a fluorometric multiplate based enzyme inhibition kit, where the ACE2 inhi-bitions of S. triloba, S. officinalis, and S. sclarea essential oils were 50.1%, 60.5%, and 72.1% at a concentration of 20 µg/mL, respectively. As a result, further tests of Salvia essential oils supported by in vivo studies may have antiviral potential ap-plications against coronaviruses due to ACE2 enzyme inhibitions. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Istanbul Medipol University | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | ACE2 | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Essential Oil | en_US |
dc.subject | Salvia | en_US |
dc.title | In vitro ACE2 enzyme inhibitory activity evaluation of different salvia essential oils | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Acta Pharmaceutica Sciencia | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-3412-0807 | en_US |
dc.authorid | 0000-0003-1896-2729 | en_US |
dc.identifier.volume | 60 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 117 | en_US |
dc.identifier.endpage | 124 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.23893/1307-2080.APS.6008 | en_US |
dc.institutionauthor | Karadağ, Ayşe Esra | |
dc.institutionauthor | Biltekin, Sevde Nur | |
dc.identifier.scopus | 2-s2.0-85130165186 | en_US |
dc.identifier.scopusquality | Q3 | en_US |