dc.contributor.author | Avnioğlu, Seda | |
dc.contributor.author | Güngör, Meltem | |
dc.contributor.author | Kurutaş, Ergül | |
dc.contributor.author | Öztürk, Ünal | |
dc.contributor.author | Demirhan, İlter | |
dc.contributor.author | Bakariş, Sevgi | |
dc.contributor.author | Velioğlu, Halil Aziz | |
dc.contributor.author | Çankaya, Şeyda | |
dc.contributor.author | Yuluğ, Burak | |
dc.date.accessioned | 2022-03-03T09:04:12Z | |
dc.date.available | 2022-03-03T09:04:12Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Avnioğlu, S., Güngör, M., Kurutaş, E., Öztürk, Ü., Demirhan, İ., Bakariş, S. ... Yuluğ, B. (2022). The effect of resveratrol on sphingosine-1 and oxidative/ nitrosative stress in an experimental heart ischemia reperfusion model. Revista Romana de Medicina de Laborator, 30(1), 9-18. https://doi.org/10.2478/rrlm-2021-0036 | en_US |
dc.identifier.issn | 1841-6624 | |
dc.identifier.issn | 2284-5623 | |
dc.identifier.uri | https://doi.org/10.2478/rrlm-2021-0036 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/9085 | |
dc.description.abstract | Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R). Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope. Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups. Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | University Press | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Resveratrol | en_US |
dc.subject | Ischemia/Reperfusion Injury | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Oxidative Stress | en_US |
dc.subject | Heart | en_US |
dc.title | The effect of resveratrol on sphingosine-1 and oxidative/ nitrosative stress in an experimental heart ischemia reperfusion model | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Revista Romana de Medicina de Laborator | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.authorid | 0000-0002-2306-5937 | en_US |
dc.identifier.volume | 30 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 9 | en_US |
dc.identifier.endpage | 18 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.2478/rrlm-2021-0036 | en_US |
dc.institutionauthor | Velioğlu, Halil Aziz | |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.wos | 000754348900001 | en_US |