dc.contributor.author | Yurttaş, Leyla | |
dc.contributor.author | Demirayak, Şeref | |
dc.contributor.author | Ilgın, Sinem | |
dc.contributor.author | Atlı, Özlem | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:35:42Z | |
dc.date.available | 10.07.201910:49:14 | |
dc.date.available | 2019-07-10T19:35:42Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Yurttaş, L., Demirayak, Ş., Ilgın, S. ve Atlı, Ö. (2014). In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells. Bioorganic and Medicinal Chemistry, 22(22), 6313-6323. https://dx.doi.org/10.1016/j.bmc.2014.10.002 | en_US |
dc.identifier.issn | 0968-0896 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.bmc.2014.10.002 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/906 | |
dc.description.abstract | A series of 1,2,4-triazine derivatives bearing piperazine amide moiety has been synthesized and investigated for their potential anticancer activities. 1-[4-(5,6-Bis (4-subtituted phenyl) -1,2,4-triazin-3-yl)piperazin-1-yl]-2-[4-(3-substituted phenyl) piperazin-1-yl]ethanone derivative (1-32) compounds were synthesized by a four step synthetic procedure. The activity studies were evaluated using XTT method, BrdU method and flow cytometric analysis on MCF-7 breast cancer cells and NIH/3T3 (mouse embryonic fibroblast cells) healthy cells. Compounds 5 with 3-chlorophenyl and compound 7 with 4-chlorophenyl substitutions were found to be promising antiproliferative agents comparing with an effective anticancer drug, cisplatin. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Ltd | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | 1,2,4-Triazine | en_US |
dc.subject | Antiproliferative Activity | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Breast Cancer | en_US |
dc.subject | Piperazine Amide | en_US |
dc.subject | XTT Method | en_US |
dc.title | In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Bioorganic and Medicinal Chemistry | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı | en_US |
dc.identifier.volume | 22 | en_US |
dc.identifier.issue | 22 | en_US |
dc.identifier.startpage | 6313 | en_US |
dc.identifier.endpage | 6323 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.bmc.2014.10.002 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q1 | en_US |