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In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells

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Date

2014

Author

Yurttaş, Leyla
Demirayak, Şeref
Ilgın, Sinem
Atlı, Özlem

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Yurttaş, L., Demirayak, Ş., Ilgın, S. ve Atlı, Ö. (2014). In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells. Bioorganic and Medicinal Chemistry, 22(22), 6313-6323. https://dx.doi.org/10.1016/j.bmc.2014.10.002

Abstract

A series of 1,2,4-triazine derivatives bearing piperazine amide moiety has been synthesized and investigated for their potential anticancer activities. 1-[4-(5,6-Bis (4-subtituted phenyl) -1,2,4-triazin-3-yl)piperazin-1-yl]-2-[4-(3-substituted phenyl) piperazin-1-yl]ethanone derivative (1-32) compounds were synthesized by a four step synthetic procedure. The activity studies were evaluated using XTT method, BrdU method and flow cytometric analysis on MCF-7 breast cancer cells and NIH/3T3 (mouse embryonic fibroblast cells) healthy cells. Compounds 5 with 3-chlorophenyl and compound 7 with 4-chlorophenyl substitutions were found to be promising antiproliferative agents comparing with an effective anticancer drug, cisplatin.

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Q2

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Source

Bioorganic and Medicinal Chemistry

Volume

22

Issue

22

URI

https://dx.doi.org/10.1016/j.bmc.2014.10.002
https://hdl.handle.net/20.500.12511/906

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