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dc.contributor.authorGünal, Mehmet Yalçın
dc.contributor.authorŞahinler Ayla, Sibel
dc.contributor.authorÇaglayan, Berrak
dc.contributor.authorBeker, Mustafa Çağlar
dc.contributor.authorBedri, Nejda
dc.contributor.authorAslan, İpek Bilge
dc.contributor.authorÖzdemir, Ekrem Musa
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorYeşilada, Elif
dc.date.accessioned2021-12-30T12:00:09Z
dc.date.available2021-12-30T12:00:09Z
dc.date.issued2021en_US
dc.identifier.citationGünal, M. Y., Şahinler Ayla, S., Çağlayan, B., Beker, M. Ç., Bedri, N., Aslan, İ. B. ... Yeşilada, E. (2021). Can Carpobrotus edulis, heal incisional and excisional wounds on the skin? Bratislava Medical Journal-Bratislavske Lekarske Listy, 122(12), 912-917. https://doi.org/10.4149/BLL_2021_147en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.urihttps://doi.org/10.4149/BLL_2021_147
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8739
dc.description.abstractOBJECTIVES: This study aimed to investigate the wound healing activity of liposomal Carpobrotus edulis powder extract (CEPE) formulation on incisional and excisional wounds in rat. BACKGROUND: In the event of any damage, the damaged tissue undergoes a process of regenerating itself, which is called wound healing. METHODS: Centella asiatica extract (CAE) was used as the reference molecule in the study. The wound healing process was tested by using the excisional and incisional wound model. On the 12th day of the study, maximum stress, stress, % of elongation values were evaluated in the incisional wound. Also; histological parameters and macroscopic photographic analyses were evaluated in the excisional wound. RESULTS: In the photo evaluations, the improvement was more prominent in both CAE and CEPE groups than in the control group. Histological evaluation showed that CEPE group had signifi cant wound healing activity compared to the control and CAE groups. Axial tensile-elongation experiments in incisional wound tissue show that there was no signifi cant difference between CAE and CEPE groups. CONCLUSION: Liposomal formulations of C.edulis extract were found to have positive effects on the healing process, both on excisional and incisional wound tissues (Tab. 2, Fig. 3, Ref. 30).en_US
dc.language.isoengen_US
dc.publisherComenius Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarpobrotus Edulisen_US
dc.subjectLiposomeen_US
dc.subjectIncisional Wounden_US
dc.subjectExcisional Wounden_US
dc.subjectAxial Tensile-Elongation Testsen_US
dc.titleCan Carpobrotus edulis, heal incisional and excisional wounds on the skin?en_US
dc.typearticleen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Tıbbi Araştırma Merkezi (MEDİTAM)en_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0001-7702-2441en_US
dc.authorid0000-0002-1332-1968en_US
dc.authorid0000-0002-5072-132Xen_US
dc.authorid0000-0002-9476-8488en_US
dc.authorid0000-0002-6029-1626en_US
dc.authorid0000-0001-9416-7757en_US
dc.authorid0000-0001-6494-8923en_US
dc.identifier.volume122en_US
dc.identifier.issue12en_US
dc.identifier.startpage912en_US
dc.identifier.endpage917en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.4149/BLL_2021_147en_US
dc.identifier.wosqualityQ3en_US
dc.identifier.scopusqualityQ3en_US


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