dc.contributor.author | Günal, Mehmet Yalçın | |
dc.contributor.author | Şahinler Ayla, Sibel | |
dc.contributor.author | Çaglayan, Berrak | |
dc.contributor.author | Beker, Mustafa Çağlar | |
dc.contributor.author | Bedri, Nejda | |
dc.contributor.author | Aslan, İpek Bilge | |
dc.contributor.author | Özdemir, Ekrem Musa | |
dc.contributor.author | Kılıç, Ertuğrul | |
dc.contributor.author | Yeşilada, Elif | |
dc.date.accessioned | 2021-12-30T12:00:09Z | |
dc.date.available | 2021-12-30T12:00:09Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Günal, M. Y., Şahinler Ayla, S., Çağlayan, B., Beker, M. Ç., Bedri, N., Aslan, İ. B. ... Yeşilada, E. (2021). Can Carpobrotus edulis, heal incisional and excisional wounds on the skin? Bratislava Medical Journal-Bratislavske Lekarske Listy, 122(12), 912-917. https://doi.org/10.4149/BLL_2021_147 | en_US |
dc.identifier.issn | 0006-9248 | |
dc.identifier.issn | 1336-0345 | |
dc.identifier.uri | https://doi.org/10.4149/BLL_2021_147 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/8739 | |
dc.description.abstract | OBJECTIVES: This study aimed to investigate the wound healing activity of liposomal Carpobrotus edulis
powder extract (CEPE) formulation on incisional and excisional wounds in rat.
BACKGROUND: In the event of any damage, the damaged tissue undergoes a process of regenerating itself,
which is called wound healing.
METHODS: Centella asiatica extract (CAE) was used as the reference molecule in the study. The wound
healing process was tested by using the excisional and incisional wound model. On the 12th day of the study,
maximum stress, stress, % of elongation values were evaluated in the incisional wound. Also; histological
parameters and macroscopic photographic analyses were evaluated in the excisional wound.
RESULTS: In the photo evaluations, the improvement was more prominent in both CAE and CEPE groups
than in the control group. Histological evaluation showed that CEPE group had signifi cant wound healing
activity compared to the control and CAE groups. Axial tensile-elongation experiments in incisional wound
tissue show that there was no signifi cant difference between CAE and CEPE groups.
CONCLUSION: Liposomal formulations of C.edulis extract were found to have positive effects on the healing
process, both on excisional and incisional wound tissues (Tab. 2, Fig. 3, Ref. 30). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Comenius University | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Carpobrotus Edulis | en_US |
dc.subject | Liposome | en_US |
dc.subject | Incisional Wound | en_US |
dc.subject | Excisional Wound | en_US |
dc.subject | Axial Tensile-Elongation Tests | en_US |
dc.title | Can Carpobrotus edulis, heal incisional and excisional wounds on the skin? | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Bratislava Medical Journal-Bratislavske Lekarske Listy | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Tıbbi Araştırma Merkezi (MEDİTAM) | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.authorid | 0000-0001-7702-2441 | en_US |
dc.authorid | 0000-0002-1332-1968 | en_US |
dc.authorid | 0000-0002-5072-132X | en_US |
dc.authorid | 0000-0002-9476-8488 | en_US |
dc.authorid | 0000-0002-6029-1626 | en_US |
dc.authorid | 0000-0001-9416-7757 | en_US |
dc.authorid | 0000-0001-6494-8923 | en_US |
dc.identifier.volume | 122 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.startpage | 912 | en_US |
dc.identifier.endpage | 917 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.4149/BLL_2021_147 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q3 | en_US |