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dc.contributor.authorArpa, Muhammet Davut
dc.contributor.authorÜnükür, Melike Zeynep
dc.contributor.authorErim, Ümit Can
dc.date.accessioned2021-10-08T08:25:07Z
dc.date.available2021-10-08T08:25:07Z
dc.date.issued2021en_US
dc.identifier.citationArpa, M. D., Ünükür, M. Z. ve Erim, Ü. C. (2021). Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films. Journal of Research in Pharmacy, 25(5), 667-680. https://dx.doi.org/10.29228/jrp.58en_US
dc.identifier.issn2630-6344
dc.identifier.urihttps://dx.doi.org/10.29228/jrp.58
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8394
dc.description.abstractBuccal administration of different active ingredients as an alternative to oral or dermal routes has been widely studied. The films are one of the most investigated dosage forms regarding the buccal formulations developed using bioadhesive polymers. Having thin and flexible structures, the films remain in the mouth for their duration of action without causing any discomfort. There are many studies conducted to develop buccal films for local treatment of oral fungal infections. In this research, buccal films were prepared using terbinafine hydrochloride, which is frequently used orally and systemically in the treatment of fungal infections and has low water solubility. The films were prepared by solvent casting method using hydroxypropyl methyl cellulose (HPMC) and polyvinyl pyrrolidone K30 (PVP) as the bioadhesive polymers and glycerin (2-3%) as the plasticizer. Characterization properties including thickness, weight uniformity, flexibility, tensile strength, swelling capacity were examined and the bioadhesive characteristics were determined by Texture Analyzer device using bovine buccal tissue. According to the findings of bioadhesion studies, the highest bioadhesive properties were detected in F1 and F7 formulations, which contained 5% HPMC. In vitro release studies exhibited that F1 and F7 film formulations with 5% HPMC represented slower and more controlled release compared to F2 and F8 film formulations having 4% HPMC + 1% PVP. The results revealed that the developed buccal formulations loaded with terbinafine hydrochloride might be convenient for the local treatment of oral fungal infections.en_US
dc.language.isoengen_US
dc.publisherMarmara Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTerbinafine Hydrochlorideen_US
dc.subjectHydroxypropyl Methylcelluloseen_US
dc.subjectPolyvinylpyrrolidoneen_US
dc.subjectBuccal Drug Deliveryen_US
dc.subjectBuccal Filmen_US
dc.titleFormulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal filmsen_US
dc.typearticleen_US
dc.relation.journalJournal of Research in Pharmacyen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalıen_US
dc.authorid0000-0001-9290-2404en_US
dc.authorid0000-0003-1422-8359en_US
dc.authorid0000-0002-4121-588Xen_US
dc.identifier.volume25en_US
dc.identifier.issue5en_US
dc.identifier.startpage667en_US
dc.identifier.endpage680en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.29228/jrp.58en_US


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