The role of serum interleukin-6 and C-reactive protein levels for differentiating aetiology of neonatal sepsis
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CitationÇelik, İ. H., Demirel, G., Uraş, N., Oǧuz, Ş. S., Erdeve, Ö., ve Dilmen, U. (2015). The role of serum interleukin-6 and C-reactive protein levels for differentiating aetiology of neonatal sepsis. Archivos Argentinos de Pediatria, 113(6), 534-537. https://dx.doi.org/10.5546/aap.2015.eng.534
Introduction: In our clinical practice, we observed high interleukin-6 (IL-6) levels in gram-negative sepsis. Objective: To investigate the relationship between IL-6 and C-reactive protein (CRP) levels and early determination of neonatal sepsis of gram-negative or gram-positive aetiology. Population and Methods: White blood cell count, IL-6 and CRP levels were compared among different groups. Results: Gram-negative, gram-positive and fungal infection groups consisted of 73, 82 and 15 patients, respectively. The optimal cut-off levels of IL-6 between gram-negative and gram-positive fungal infection groups were 202 and 57 pg/ ml. The fungal infection group had higher CRP levels than gram-negative and positive infection groups. Conclusions: To our knowledge, this is the largest reported study aiming at determining of IL-6 cut-off levels to differentiate neonatal sepsis aetiology. Gram-negative microorganisms led to 10 fold higher IL-6 production. The evaluation of IL-6 and CRP is useful to diagnose and also differentiate neonatal sepsis aetiology.