The role of serum interleukin-6 and C-reactive protein levels for differentiating aetiology of neonatal sepsis
Künye
Çelik, İ. H., Demirel, G., Uraş, N., Oǧuz, Ş. S., Erdeve, Ö., ve Dilmen, U. (2015). The role of serum interleukin-6 and C-reactive protein levels for differentiating aetiology of neonatal sepsis. Archivos Argentinos de Pediatria, 113(6), 534-537. https://dx.doi.org/10.5546/aap.2015.eng.534Özet
Introduction: In our clinical practice, we observed high interleukin-6 (IL-6) levels in gram-negative sepsis. Objective: To investigate the relationship between IL-6 and C-reactive protein (CRP) levels and early determination of neonatal sepsis of gram-negative or gram-positive aetiology. Population and Methods: White blood cell count, IL-6 and CRP levels were compared among different groups. Results: Gram-negative, gram-positive and fungal infection groups consisted of 73, 82 and 15 patients, respectively. The optimal cut-off levels of IL-6 between gram-negative and gram-positive fungal infection groups were 202 and 57 pg/ ml. The fungal infection group had higher CRP levels than gram-negative and positive infection groups. Conclusions: To our knowledge, this is the largest reported study aiming at determining of IL-6 cut-off levels to differentiate neonatal sepsis aetiology. Gram-negative microorganisms led to 10 fold higher IL-6 production. The evaluation of IL-6 and CRP is useful to diagnose and also differentiate neonatal sepsis aetiology.
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Archivos Argentinos de PediatriaCilt
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