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dc.contributor.authorŞahin, Zafer
dc.contributor.authorBiltekin, Sevde Nur
dc.contributor.authorYurttaş, Leyla
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned2021-06-10T05:55:12Z
dc.date.available2021-06-10T05:55:12Z
dc.date.issued2021en_US
dc.identifier.citationŞahin, Z., Biltekin, S. N., Yurttaş, L. ve Demirayak, Ş. (2021). Synthesis, characterization and antibacterial evaluation of new pyridyl-thiazole hybrids of sulfonamides. Istanbul Journal of Pharmacy, 51(1), 67-72. https://dx.doi.org/10.26650/IstanbulJPharm.2020.0083en_US
dc.identifier.issn2587-2087
dc.identifier.urihttps://dx.doi.org/10.26650/IstanbulJPharm.2020.0083
dc.identifier.urihttps://hdl.handle.net/20.500.12511/7118
dc.description.abstractBackground and Aims: Sulfonamide drugs are a very old and noted group of small molecules, and are still one of the most important antimicrobial compounds. In this study, starting from sulfonamide drugs, new original compounds containing frequent and functional rings such as thiazole and pyridine were synthesized and their antimicrobial effects were evaluated. Methods: Eighteen new compounds were synthesized by converting the 4-amino group of the sulfonamides to thiourea, and continued by thiazole ring closure. Characterization of the compounds was carried out by FT-IR, H-1-NMR and C-13-NMR and HRMS. MIC values were obtained in antimicrobial activity studies, which were carried out by Broth Microdilution method. Results: Compounds 3p-r had an effect of 32 mu g/ml against B. spizizenii. In addition, compounds 3d-f and 3p-r each showed effect against different gram-positive bacteria. Compound 3r had an MIC of 128 mu g/mL against gram-negative organisms. The rest of the series did not affect gram-negative bacteria. In the study, chloramphenicol and sulfamethoxazole were used as standards. Conclusion: Sulfanilamide and sulfadiazine derivatives showed higher inhibitory effects compared to the rest of the series. 3d-f and 3p-r showed inhibitor activity against gram-positive bacteria, conversely to the standard drug sulfamethoxazole, which possibly means that the mechanism of action is not same.en_US
dc.language.isoengen_US
dc.publisherIstanbul Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectSulfonamideen_US
dc.subjectThiazoleen_US
dc.subjectAntibacterialen_US
dc.titleSynthesis, characterization and antibacterial evaluation of new pyridyl-thiazole hybrids of sulfonamidesen_US
dc.typearticleen_US
dc.relation.ispartofIstanbul Journal of Pharmacyen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-5976-676Xen_US
dc.authorid0000-0003-1896-2729en_US
dc.authorid0000-0002-0841-1299en_US
dc.identifier.volume51en_US
dc.identifier.issue1en_US
dc.identifier.startpage67en_US
dc.identifier.endpage72en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.26650/IstanbulJPharm.2020.0083en_US


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