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dc.contributor.authorŞakul, Ayşe Arzu
dc.contributor.authorKurtul, Ekin
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorKırmızı, Neriman İpek
dc.contributor.authorBahtiyar, Bade Cevriye
dc.contributor.authorSaltan, Hayriye
dc.contributor.authorBahadır Acıkara, Özlem
dc.date.accessioned2021-05-03T08:44:47Z
dc.date.available2021-05-03T08:44:47Z
dc.date.issued2021en_US
dc.identifier.citationŞakul, A. A., Kurtul, E., Özbek, H., Kırmızı, N. İ., Bahtiyar, B. C., Saltan, H. ... Bahadır Acıkara, Ö. (2021). Evaluation of antidiabetic activities of scorzonera species on alloxan-induced diabetic mice. Clinical and Experimental Health Sciences, 11(1), 74-80. https://dx.doi.org/10.33808/clinexphealthsci.797747en_US
dc.identifier.issn2459-1459
dc.identifier.urihttps://dx.doi.org/10.33808/clinexphealthsci.797747
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6801
dc.description.abstractObjective: In Turkish folk medicine, different species of Scorzonera (Asteraceae) have been used in the treatment of various disorders. The study aimed to investigate antidiabetic activity of Scorzonera species and if rutin is the primary component responsible of this activity. Methods: The extracts of aerial parts of Scorzonera tomentosa, S. mollis ssp. szowitsii, S. suberosa ssp. suberosa, S. eriophora, S. acuminata, S. sublanata and S. cana var. jacquiniana were used in the experiment. Additionally, rutin, which has been analysed and detected by using HPLC qualitatively and quantitatively in some Scorzonera species, was also tested for its antidiabetic activity in the same conditions. An alloxan-induced diabetic mice test model was used in order to verify antidiabetic activity. Antidiabetic activities of the 9 groups (n=5; each) were measured at four different times: before Scorzonera extracts and rutin treatment and after 1, 2 and 4 hours of treatments. Results: S. sublanata extract exhibited the highest antidiabetic activity and at 100 mg/kg dose, it significantly reduced blood glucose levels measured after 1, 2 and 4 hours of treatments when compared to isotonic saline solution group (diabetic control group). S. cana var. jacquiniana extract also displayed notable decrease after 4 hours of treatment. Significant lowering effect on blood glucose level was also observed by treatment with rutin in all tested times at 100 mg/kg i.p. injection. According to the HPLC analyses the highest rutin content was determined in the S. acuminata aerial parts. Conclusion: Rutin content and the antidiabetic activity of the plant extracts were not correlated as displayed in this present study. Further studies should be performed to reveal responsible compunds for antidiabetic activity.en_US
dc.language.isoengen_US
dc.publisherMarmara University Faculty of Health Sciencesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlloxanen_US
dc.subjectAntidiabetic Activityen_US
dc.subjectDiabetesen_US
dc.subjectRutinen_US
dc.subjectScorzoneraen_US
dc.titleEvaluation of antidiabetic activities of scorzonera species on alloxan-induced diabetic miceen_US
dc.typearticleen_US
dc.relation.journalClinical and Experimental Health Sciencesen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Ana Bilim Dalıen_US
dc.authorid0000-0002-9354-0000en_US
dc.authorid0000-0001-8294-0802en_US
dc.authorid0000-0002-9971-1122en_US
dc.identifier.volume11en_US
dc.identifier.issue1en_US
dc.identifier.startpage74en_US
dc.identifier.endpage80en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.33808/clinexphealthsci.797747en_US


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