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dc.contributor.authorEdsall, Connor
dc.contributor.authorKhan, Zerin Mahzabin
dc.contributor.authorMancia, Lauren
dc.contributor.authorHall, Sarah
dc.contributor.authorMustafa, Waleed
dc.contributor.authorJohnsen, Eric
dc.contributor.authorKlibanov, Alexander L.
dc.contributor.authorYüksel Durmaz, Yasemin
dc.contributor.authorVlaisavljevich, Eli
dc.date.accessioned2021-03-12T11:35:29Z
dc.date.available2021-03-12T11:35:29Z
dc.date.issued2021en_US
dc.identifier.citationEdsall, C., Khan, Z. M., Mancia, L., Hall, S., Mustafa, W., Johnsen, E. ... Vlaisavljevich, E. (2021). Bubble cloud behavior and ablation capacity for histotripsy generated from intrinsic or artificial cavitation nuclei. Ultrasound in Medicine and Biology, 47(3), 620-639. https://dx.doi.org/10.1016/j.ultrasmedbio.2020.10.020en_US
dc.identifier.issn0301-5629
dc.identifier.issn1879-291X
dc.identifier.urihttps://dx.doi.org/10.1016/j.ultrasmedbio.2020.10.020
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6610
dc.description.abstractThe study described here examined the effects of cavitation nuclei characteristics on histotripsy. Highspeed optical imaging was used to compare bubble cloud behavior and ablation capacity for histotripsy generated from intrinsic and artificial cavitation nuclei (gas-filled microbubbles, fluid-filled nanocones). Results showed a significant decrease in the cavitation threshold for microbubbles and nanocones compared with intrinsic-nuclei controls, with predictable and well-defined bubble clouds generated in all cases. Red blood cell experiments showed complete ablations for intrinsic and nanocone phantoms, but only partial ablation in microbubble phantoms. Results also revealed a lower rate of ablation in artificial-nuclei phantoms because of reduced bubble expansion (and corresponding decreases in stress and strain). Overall, this study demonstrates the potential of using artificial nuclei to reduce the histotripsy cavitation threshold while highlighting differences in the bubble cloud behavior and ablation capacity that need to be considered in the future development of these approaches.en_US
dc.description.sponsorshipNational Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (NIH) ; Virginia Tech Institute for Critical Technology and Applied Science (ICTAS) ; United States Department of Health & Human Services National Institutes of Health (NIH) - USA ; Turkish Academy of Sciences through its Outstanding Young Scientist Award Program (TUBA-GEBIP) ; Office of Naval Researchen_US
dc.language.isoengen_US
dc.publisherElsevier Science Incen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHistotripsyen_US
dc.subjectMicrotripsyen_US
dc.subjectNanoparticlesen_US
dc.subjectMicrobubblesen_US
dc.subjectCavitationen_US
dc.subjectAblationen_US
dc.titleBubble cloud behavior and ablation capacity for histotripsy generated from intrinsic or artificial cavitation nucleien_US
dc.typearticleen_US
dc.relation.journalUltrasound in Medicine and Biologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0003-2776-5807en_US
dc.identifier.volume47en_US
dc.identifier.issue3en_US
dc.identifier.startpage620en_US
dc.identifier.endpage639en_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/118 Z324
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.ultrasmedbio.2020.10.020en_US


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