Assessment of clinical features and renal functions in Coronavirus disease-19: A retrospective analysis of 96 patients
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info:eu-repo/semantics/openAccessTarih
2020Yazar
Kutluhan, Musab AliTaş, Ahmet
Şahin, Aytaç
Ürkmez, Ahmet
Topaktaş, Ramazan
Ataç, Ömer
Verit, Ayhan
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Kutluhan, M. A., Taş, A., Şahin, A., Ürkmez, A., Topaktaş, R., Ataç, Ö. ... Verit, A. (2020). Assessment of clinical features and renal functions in Coronavirus disease-19: A retrospective analysis of 96 patients. International Journal of Clinical Practice, 74(12). https://dx.doi.org/10.1111/ijcp.13636Özet
Background The most common extra pulmonary organ dysfunction in acute respiratory distress syndrome is acute kidney injury. Current data so far indicate low incidence of AKI in Covid-19 disease. Objective In this retrospective study, we analysed the clinical features of patients diagnosed with Covid-19 and investigated the effect of Covid-19 on kidney function. Methods Ninety-six patients diagnosed with Covid-19 were included in our study. Demographic features (Age, gender, co-morbidities), symptoms, thorax CT findings, Covid-19 PCR results and laboratory findings were recorded. The clinical features of the patients were analysed and kidney function values before Covid-19 diagnosis were compared with kidney function values after Covid-19 diagnosis. Results Most presenting symptom was fever (51%). Most accompanying co-morbidity was hypertension (56%). According to laboratory findings; ferritin, D-dimer and C-reactive protein levels were statistically significantly higher in ARDS group than severe pneumonia and pneumonia group (P = .002,P = .001 andP < .001, respectively). Also lymphocyte levels were statistically significantly lower in ARDS group than severe pneumonia and pneumonia group (P = .042). According to KDIGO criteria 3 (3.1%) patients had AKI during the hospital stay. For all patients, there was statistically significant difference between basal, 1st, 5th and 10th day BUN and SCr levels (P = .024 andP = .018, respectively). For severe pneumonia group there was statistically significant difference between basal, 1st, 5th and 10th day SCr levels (P = .045). Conclusion Our study demonstrated that Covid-19 can cause renal impairment both with pneumonia and ARDS. A large-scale prospective randomised studies are needed to reach final judgement about this topic.
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International Journal of Clinical PracticeCilt
74Sayı
12Koleksiyonlar
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