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Functional neural networks stratify Parkinson's disease patients across the spectrum of cognitive impairment
(Wiley, 2024)Introduction Cognitive impairment (CI) is a significant non-motor symptoms in Parkinson's disease (PD) that often precedes the emergence of motor symptoms by several years. Patients with PD hypothetically progress from ... -
Gamma-amino butyric acid immunoreactivity in the testis tissue of wistar and genetic absence epilepsy rats
(Soc Chilena Anatomia, 2021)Studies have shown the adverse effects of epileptic seizures on reproductive health. The aim of the present study was to investigate morphological changes, apoptosis and GABA localization in the testis tissue of genetic ... -
Ghrelin regulates expression of the transcription factor Pax6 in hypoxic brain progenitor cells and neurons
(MDPI, 2022)The nature of brain impairment after hypoxia is complex and recovery harnesses different mechanisms, including neuroprotection and neurogenesis. Experimental evidence suggests that hypoxia may trigger neurogenesis postnatally ... -
High-resolution mapping of sensory fibers at the healthy and post-myocardial infarct whole transgenic hearts
(Wiley, 2023)The sensory nervous system is critical to maintain cardiac function. As opposed to efferent innervation, less is known about cardiac afferents. For this, we mapped the VGLUT2-expressing cardiac afferent fibers of spinal ... -
A histopathological evaluation of ovarian hyperstimulation syndrome on reproductive and vital organs and the role of the VEGF-PKA pathway in a mouse model
(Karger, 2021)Ovarian hyperstimulation syndrome (OHSS) is one of the most common and iatrogenic complications of in vitro fertilization therapy, which is an exaggerated response to excess hormones resulting in the development of a large ... -
Human macrophages directly modulate iPSC-derived cardiomyocytes at healthy state and congenital arrhythmia model in vitro
(Springer Heidelberg, 2022)The electrophysiological regulation of cardiomyocytes (CMs) by the cardiac macrophages (M Phi s) has been recently described as an unconventional role of M Phi s in the murine heart. Investigating the molecular and ... -
Identification of PDE10A related proteins via proteomic analysis
(İnönü University Faculty of Medicine, 2022)Aim: Phosphodiesterase 10A (PDE10A) regulates the expression of secondary messengers of cyclic adenosine monophosphate and cyclic guanosine monophosphate, which control several intracellular signaling pathways. Recently, ... -
Identification of protein-protein interaction bridges for multiple sclerosis
(Oxford University Press, 2023)Motivation: Identifying and prioritizing disease-related proteins is an important scientific problem to develop proper treatments. Network science has become an important discipline to prioritize such proteins. Multiple ... -
The IL-25/ILC2 axis promotes lung cancer with a concomitant accumulation of immune-suppressive cells in tumors in humans and mice
(Frontiers Media SA, 2023)Background: Group 2 innate lymphoid cells (ILC2) can be activated by interleukin (IL)-33 or IL-25. IL-25-activated ILC2 cells help protect the host against helminth infection while exacerbating allergic-like inflammation ... -
IL13 fused pseudomonas exotoxin targets various cancers in vitro
(International Institute of Anticancer Research, 2021)Background/Aim: Pseudomonas exotoxin (PE) is one of the most widely used toxins in the construction of therapeutic fusion proteins in pre-clinical studies followed by phase trials. In principle, PE acts by blocking protein ... -
Immature event-related alpha dynamics in children compared with the young adults during inhibition shown by day-night stroop task
(Frontiers Media SA, 2023)Introduction: Inhibitory control develops gradually from infancy to childhood and improves further during adolescence as the brain matures. Related previous studies showed the indispensable role of task-related alpha power ... -
An improved platform for cultured neuronal network electrophysiology: Multichannel optogenetics integrated with MEAs
(Springer, 2022)Cultured neuronal networks (CNNs) are powerful tools for studying how neuronal representation and adaptation emerge in networks of controlled populations of neurons. To ensure the interaction of a CNN and an artificial ... -
In 2D and 3D cell culture models, effects of endothelial cells on E-cadherin / β-catenin expression levels and spheroid sizes in ishikawa cells
(Asian Pacific Organization for Cancer Prevention, 2022)Increasing evidence shows that three dimensional cell culture models better reflect the in vivo tumor microenvironment than two dimensional cell culture models. Co-culture models are ideal cell culture models for understanding ... -
An in silico investigation of anticancer peptide candidates in fermented food microbiomes
(Istanbul University, 2023)Objective: Cancer is a leading cause of death worldwide, requires development of new effective, specific, and safe strategies that do not carry the disadvantages of traditional cancer treatment approaches. Hence, this study ... -
In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model
(Elsevier B.V., 2021)Ischemic cerebral stroke is one of the leading causes of death and disability in humans. However, molecular processes underlying the development of this pathology remain poorly understood. There are major gaps in our ... -
In vivo wound-healing and in vitro antibacterial and antioxidant properties of Carduus adpressus extract
(Marmara University, 2023)Carduus adpressus has been used for its anti-hair loss effect in traditional folk medicine. The plant species is mainly distributed in Türkiye, Bulgaria, and the Western Caucasus. The studies on this specific plant in the ... -
Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
(NLM (Medline), 2022)Undruggability of RAS proteins has necessitated alternative strategies for the development of effective inhibitors. In this respect, phosphorylation has recently come into prominence as this reversible post-translational ... -
Inhibition of SARS-CoV-2 main protease: A repurposing study that targets the dimer interface of the protein
(Taylor and Francis Ltd., 2022)Coronavirus disease-2019 (COVID-19) was firstly reported in Wuhan, China, towards the end of 2019, and emerged as a pandemic. The spread and lethality rates of the COVID-19 have ignited studies that focus on the development ... -
Instant determination of the artemisinin from various Artemisia annua L. extracts by LC-ESI-MS/MS and their in-silico modelling and in vitro antiviral activity studies against SARS-CoV-2
(Wiley, 2022)Introduction Numerous efforts in natural product drug development are reported for the treatment of Coronavirus. Based on the literature, among these natural plants Artemisia annua L. shows some promise for the treatment ... -
Integrin α5β1 mediated cellular reorganization in human mesenchymal stem cells during neuronal differentiation
(International Institute of Anticancer Research, 2021)Background/Aim: Mesenchymal stem cells (MSCs) have been widely used for yielding neurons in culture to study nervous system pathologies and develop regenerative approaches. In this study, cellular rearrangements of human ...
