Güncel Gönderiler: Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü (SABİTA)
Toplam kayıt 213, listelenen: 61-80
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Resting state electroencephalographic alpha rhythms predict and are sensitive to Alzheimer's disease mild cognitive impairment progression at a 6-month follow-up
(Elsevier, 2023)Introduction: Patients with Alzheimer’s disease and mild cognitive impairment (ADMCI) suffer not only from severe cognitive deficits and disabilities in daily living but also from vigilance dysregulation reflected by ... -
The acute effect of different NAD plus precursors included in the combined metabolic activators
(Elsevier Science Inc, 2023)NAD+ and glutathione precursors are currently used as metabolic modulators for improving the metabolic conditions associated with various human diseases, including non-alcoholic fatty liver disease, neurodegenerative ... -
Reactivity of posterior cortical electroencephalographic alpha rythms during eyes opening in cognitively intact older adults and patients with dementia due to Alzheimer's and lewy diseases
(Elsevier, 2023)Introduction: Patients with Lewy Bodies (DLB) and Parkinson’s disease dementia (PDD) suffer from vigilance dysregulation reflected by hypersomnolence, cognitive fluctuations, hallucinations, and sleep disorders. Therefore, ... -
Event-related brain oscillatory responses topographically differentiated between visual and auditory emotional stimuli
(Elsevier, 2023)Previous EEG studies using emotional stimuli have successfully demonstrated that EEG-brain oscillation responses are sensitive to the valance and arousal of the stimulus. While the valance is represented by increased beta ... -
Determination of antioxidant, anticancer, antidiabetic and antimicrobial activities of Turkish red pine (Pinus brutia Ten.) bark ultrasound-assisted extract as a functional food additive
(Akademiai Kiado Zrt., 2023)Turkish red pine (Pinus brutia Ten.) is an important tree species that grows widely in Turkiye. In this study, Box-Behnken experimental design was created and optimised for ultrasound assisted extraction of bioactive ... -
Preconditioned extracellular vesicles from hypoxic microglia reduce poststroke AQP4 depolarization, disturbed cerebrospinal fluid flow, astrogliosis, and neuroinflammation
(NLM (Medline), 2023)Background: Stroke stimulates reactive astrogliosis, aquaporin 4 (AQP4) depolarization and neuroinflammation. Preconditioned extracellular vesicles (EVs) from microglia exposed to hypoxia, in turn, reduce poststroke brain ... -
Simultaneous manipulation and imaging of chemogenetically induced hydrogen peroxide in hardly transfectable endothelial cells
(Sivas Cumhuriyet University, 2022)Hydrogen peroxide (H2O2) is a critical signaling molecule in vascular cells, which controls signaling events, yet it can cause pathological oxidative stress in excess. The lack of suitable tools undermined experimental ... -
Blood viscosity and inflammatory indices in treatment-resistant schizophrenia: A retrospective cross-sectional study
(Kare Publishing, 2023)Objective: Alterations in blood flow and inflammation may be associated with the treatment response of psychotic disorders. However, changes in blood viscosity in patients with treatment-resistant schizophrenia (TRS) have ... -
Development of a chemogenetic approach to manipulate intracellular pH
(American Chemical Society, 2023)Chemogenetic Operation of iNTRacellular prOton Levels(pH-Control)is a novel substrate-based enzymatic method that enables precise spatiotemporalcontrol of ultralocal acidification in cultured cell lines and primaryneurons. ... -
Design of IKVAV peptide/gold nanoparticle decorated, micro/nano-channeled PCL/PLGA film scaffolds for neuronal differentiation and neurite outgrowth
(Elsevier Ltd, 2023)In the field of neural tissue engineering, intensive efforts are being made to develop tissue scaffolds that can support an effective functional recovery and neural development by guiding damaged axons and neurites. ... -
Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl
(Elsevier Inc., 2023)The Hippo pathway plays an imperative role in cellular processes such as differentiation, regeneration, cell migration, organ growth, apoptosis, and cell cycle. Transcription coregulator component of Hippo pathway, YAP1, ... -
Chemogenetic tools and genetic biosensors in redox biology: Probing Hyper7 signals in specific cellular locales
(Elsevier Science Inc., 2023)H2O2 is one of the most studied reactive oxygen species (ROS) in redox biology because of its critical role in oxidant-dependent signaling pathways. Conventional approaches apply exogenous H2O2 on cells and tissues, which ... -
The effects of gold nanoparticles with different surface coatings and sizes on biochemical parameters in mice
(Prusa Medical Publishing, 2023)Objectives: Gold nanoparticles are very popular metallic nanomaterials and they have a wide spectrum of biomedical applications. This study was aimed to the production of stable and monodisperse polyethyleneimine (PEI) and ... -
A proteomic analysis for profiling NeuroD2 related changes in N2A neuroblastoma cell line
(Inönü University Faculty of Medicine, 2023)Aim: NeuroD2 transcription factor is a key regulator of neurogenin-NeuroD signaling network and induces neuronal development, differentiation, neurogenesis and calcium de- pendent signaling. NeuroD2 regulates expression ... -
Wound healing activity of arum maculatum
(Istanbul Medeniyet University, 2023)Objective: In this study, the antioxidant properties of Arum maculatum plant were evaluated. This study reported for the first time the wound healing activity of the methanol extract of A. maculatum fruits. This study aimed ... -
Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators
(Elsevier Inc., 2023)Growing evidence suggests that the depletion of plasma NAD+ and glutathione (GSH) may play an important role in the development of metabolic disorders. The administration of Combined Metabolic Activators (CMA), consisting ... -
Üstün zekâlı çocukların annelerinin gebelik sürecindeki beslenme alışkanlıklarının saptanması: Retrospektif bir çalışma
(Türkiye Klinikleri, 2023)Amaç: Bu araştırmada, üstün zekâlı çocuğu olan annelerin gebelik dönemindeki beslenme al ışkanlıklarının araştırılması ve kontrol grubu ile karşılaştırılması amaçlanmıştır. Gereç ve Yöntemler: Retrospektif ve ta- nımlayıcı ... -
An in silico investigation of anticancer peptide candidates in fermented food microbiomes
(Istanbul University, 2023)Objective: Cancer is a leading cause of death worldwide, requires development of new effective, specific, and safe strategies that do not carry the disadvantages of traditional cancer treatment approaches. Hence, this study ... -
Cannabidiol as a potential novel treatment for endometriosis by its anti-inflammatory, antioxidative and antiangiogenic effects in an experimental rat model
(Elsevier Science Ltd, 2023)Research question: Can cannabidiol (CBD) be used in the treatment of endometriosis for its anti-inflammatory, antioxidative and antiangiogenic effects? Design: Endometrial implants were surgically induced in 36 female ... -
Network-medicine approach for the identification of genetic association of parathyroid adenoma with cardiovascular disease and type-2 diabetes
(Oxford University Press, 2023)Primary hyperparathyroidism is caused by solitary parathyroid adenomas (PTAs) in most cases (⁓85%), and it has been previously reported that PTAs are associated with cardiovascular disease (CVD) and type-2 diabetes (T2D). ...