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Toplam kayıt 76, listelenen: 21-30
The effects of gold nanoparticles with different surface coatings and sizes on biochemical parameters in mice
(Prusa Medical Publishing, 2023)
Objectives: Gold nanoparticles are very popular metallic nanomaterials and they have a wide spectrum of biomedical applications. This study was aimed to the production of stable and monodisperse polyethyleneimine (PEI) and ...
Synthesis of novel hybrid lonidamine-coumarin derivatives and their anticancer activities
(Elsevier B.V., 2023)
In order to develop drugs against cancer, which is one of the deadliest diseases in the world, hybridizing structures with known anticancer activity can provide a dual activity for the treatment of cancer cases. For this ...
Chemogenetic tools and genetic biosensors in redox biology: Probing Hyper7 signals in specific cellular locales
(Elsevier Science Inc., 2023)
H2O2 is one of the most studied reactive oxygen species (ROS) in redox biology because of its critical role in oxidant-dependent signaling pathways. Conventional approaches apply exogenous H2O2 on cells and tissues, which ...
Identification of protein-protein interaction bridges for multiple sclerosis
(Oxford University Press, 2023)
Motivation: Identifying and prioritizing disease-related proteins is an important scientific problem to develop proper treatments. Network science has become an important discipline to prioritize such proteins. Multiple ...
Development of a chemogenetic approach to manipulate intracellular pH
(American Chemical Society, 2023)
Chemogenetic Operation of iNTRacellular prOton Levels(pH-Control)is a novel substrate-based enzymatic method that enables precise spatiotemporalcontrol of ultralocal acidification in cultured cell lines and primaryneurons. ...
Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators
(Elsevier Inc., 2023)
Growing evidence suggests that the depletion of plasma NAD+ and glutathione (GSH) may play an important role in the development of metabolic disorders. The administration of Combined Metabolic Activators (CMA), consisting ...
Blood viscosity and inflammatory indices in treatment-resistant schizophrenia: A retrospective cross-sectional study
(Kare Publishing, 2023)
Objective: Alterations in blood flow and inflammation may be associated with the treatment response of psychotic disorders. However, changes in blood viscosity in patients with treatment-resistant schizophrenia (TRS) have ...
Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl
(Elsevier Inc., 2023)
The Hippo pathway plays an imperative role in cellular processes such as differentiation, regeneration, cell migration, organ growth, apoptosis, and cell cycle. Transcription coregulator component of Hippo pathway, YAP1, ...
Determination of antioxidant, anticancer, antidiabetic and antimicrobial activities of Turkish red pine (Pinus brutia Ten.) bark ultrasound-assisted extract as a functional food additive
(Akademiai Kiado Zrt., 2023)
Turkish red pine (Pinus brutia Ten.) is an important tree species that grows widely in Turkiye. In this study, Box-Behnken experimental design was created and optimised for ultrasound assisted extraction of bioactive ...
Preconditioned extracellular vesicles from hypoxic microglia reduce poststroke AQP4 depolarization, disturbed cerebrospinal fluid flow, astrogliosis, and neuroinflammation
(NLM (Medline), 2023)
Background: Stroke stimulates reactive astrogliosis, aquaporin 4 (AQP4) depolarization and neuroinflammation. Preconditioned extracellular vesicles (EVs) from microglia exposed to hypoxia, in turn, reduce poststroke brain ...