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Toplam kayıt 35, listelenen: 21-30
IL13 fused pseudomonas exotoxin targets various cancers in vitro
(International Institute of Anticancer Research, 2021)
Background/Aim: Pseudomonas exotoxin (PE) is one of the most widely used toxins in the construction of therapeutic fusion proteins in pre-clinical studies followed by phase trials. In principle, PE acts by blocking protein ...
The effects of increased glucose level and glycolysis on SARS CoV-2 infection
(Bentham Science Publishers, 2022)
COVID-19 has entered our lives as an infection with high mortality rates. Although the vaccination process has provided benefits, the death toll remains frightening worldwide. Therefore, drugs and combined therapies that ...
Effects of whey Protein, Omega-3 Fatty Acid and Roux-En-Y gastric bypass on body weight, biochemical parameters and organ functions in an obese rat model: Experimental research
(Springer, 2023)
Purpose: Extreme obesity (EO) is one of the biggest public health problems in the world and has grown considerably over the years. The aim of the study is to examine the effect of Roux-en-Y gastric bypass (RYGB), whey ...
Replating protocol for human induced pluripotent stem cell–derived cardiomyocytes
(Humana Press Inc., 2022)
Human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CM) create an unlimited cell source for basic and translational cardiac research. Obtaining hiPSC-CM culture as a single-cell, monolayer or three-dimensional ...
Revealing nervous and cardiac system interactions by iPSC-Based platforms
(Elsevier, 2022)
Cardiac function is regulated by the autonomic nervous system. In exchange, the sensorial information from the heart is relayed to the brain via sensory neurons as a crucial modulatory feedback mechanism. Cardiovascular ...
Human macrophages directly modulate iPSC-derived cardiomyocytes at healthy state and congenital arrhythmia model in vitro
(Springer Heidelberg, 2022)
The electrophysiological regulation of cardiomyocytes (CMs) by the cardiac macrophages (M Phi s) has been recently described as an unconventional role of M Phi s in the murine heart. Investigating the molecular and ...
Cardiac immunology: A new era for immune cells in the heart
(Plenum Press, 2021)
The immune system is essential for the development and homeostasis of the human body. Our current understanding of the immune system on disease pathogenesis has drastically expanded over the last decade with the definition ...
The unconventional growth factors cerebral dopamine neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor promote post-ischemic neurological recovery, perilesional brain remodeling, and lesion-remote axonal plasticity
(Springer, 2023)
Considerable efforts are currently made to develop strategies that boost endogenous recovery once a stroke has occurred. Owing to their restorative properties, neurotrophic factors are attractive candidates that capitalize ...
A transcriptome based approach to predict candidate drug targets and drugs for Parkinson's disease using an in vitro 6-OHDA model
(Royal Society of Chemistry, 2023)
The most common treatment strategies for Parkinson's disease (PD) aim to slow down the neurodegeneration process or control the symptoms. In this study, using an in vitro PD model we carried out a transcriptome-based drug ...
The effects of transcranial focused ultrasound stimulation of nucleus accumbens on neuronal gene expression and brain tissue in high alcohol-preferring rats
(Springer, 2023)
We investigated the effect of low-intensity focused ultrasound (LIFU) on gene expression related to alcohol dependence and histological effects on brain tissue. We also aimed at determining the miRNA-mRNA relationship and ...