dc.contributor.author | Sibai, Mustafa | |
dc.contributor.author | Altuntaş, Ebru | |
dc.contributor.author | Yıldırım, Berna | |
dc.contributor.author | Öztürk, Gürkan | |
dc.contributor.author | Yıldırım, Süleyman | |
dc.contributor.author | Demircan, Turan | |
dc.date.accessioned | 2020-11-16T06:51:45Z | |
dc.date.available | 2020-11-16T06:51:45Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Sibai, M., Altuntaş, E., Yıldırım, B., Öztürk, G., Yıldırım, S. ve Demircan, T. (2020). Microbiome and longevity: High abundance of longevity-linked muribaculaceae in the gut of the long-living rodentspalax leucodon. OMICS: A Journal of Integrative Biology, 24(10), 592-601. https://dx.doi.org/10.1089/omi.2020.0116 | en_US |
dc.identifier.issn | 1536-2310 | |
dc.identifier.issn | 1557-8100 | |
dc.identifier.uri | https://dx.doi.org/10.1089/omi.2020.0116 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/6031 | |
dc.description.abstract | With a world population living longer as well as marked disparities in life expectancy, understanding the determinants of longevity is one of the priority research agendas in 21st century life sciences. To this end, the blind mole-rat (Spalax leucodon), a subterranean mammalian, has emerged as an exceptional model organism due to its astonishing features such as remarkable longevity, hypoxia and hypercapnia tolerance, and cancer resistance. The microbiome has been found to be a vital parameter for cellular physiology and it is safe to assume that it has an impact on life expectancy. Although the unique characteristics ofSpalaxmake it an ideal experimental model for longevity research, there is limited knowledge of the bacterial composition ofSpalaxmicrobiome, which limits its in-depth utilization. In this study, using 16S rRNA amplicon sequencing, we report the gut and skin bacterial structure ofSpalaxfor the first time. The diversity between fecal and skin samples was manifested in the distant clustering, as revealed by beta diversity analysis. Importantly, the longevity-linked Muribaculaceae bacterial family was found to be the dominating bacterial taxa inSpalaxfecal samples. These new findings contribute toward further development ofSpalaxas a model for longevity research and potential linkages between microbiome composition and longevity. | en_US |
dc.description.sponsorship | National Institute of Allergy and Infectious Diseases (NIAID) Office of Cyber Infrastructure and Computational Biology (OCICB) in Bethesda, MD | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Mary Ann Liebert Inc | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Microbiome | en_US |
dc.subject | Longevity | en_US |
dc.subject | Aging Research | en_US |
dc.subject | Spalax | en_US |
dc.subject | Muribaculaceae | en_US |
dc.subject | 16S rRNA Sequencing | en_US |
dc.title | Microbiome and longevity: High abundance of longevity-linked muribaculaceae in the gut of the long-living rodentspalax leucodon | en_US |
dc.type | article | en_US |
dc.relation.ispartof | OMICS: A Journal of Integrative Biology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-4479-2586 | en_US |
dc.authorid | 0000-0003-0352-1947 | en_US |
dc.authorid | 0000-0002-2752-1223 | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.startpage | 592 | en_US |
dc.identifier.endpage | 601 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1089/omi.2020.0116 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q2 | en_US |