dc.contributor.author | Pascarelli, Maria Teresa | |
dc.contributor.author | Del Percio, Claudio | |
dc.contributor.author | De Pandis, Maria Francesca | |
dc.contributor.author | Ferri, Raffaele | |
dc.contributor.author | Lizio, Roberta | |
dc.contributor.author | Noce, Giuseppe | |
dc.contributor.author | Lopez, Susanna | |
dc.contributor.author | Rizzo, Marco | |
dc.contributor.author | Soricelli, Andrea | |
dc.contributor.author | Nobili, Flavio | |
dc.contributor.author | Arnaldi, Dario | |
dc.contributor.author | Fama, Francesco | |
dc.contributor.author | Orzi, Francesco | |
dc.contributor.author | Buttinelli, Carla | |
dc.contributor.author | Giubilei, Franco | |
dc.contributor.author | Salvetti, Marco | |
dc.contributor.author | Cipollini, Virginia | |
dc.contributor.author | Franciotti, Raffaella | |
dc.contributor.author | Onofri, Marco | |
dc.contributor.author | Fuhr, Peter | |
dc.contributor.author | Gschwandtner, Ute | |
dc.contributor.author | Ransmayr, Gerhard | |
dc.contributor.author | Aarsland, Dag | |
dc.contributor.author | Parnetti, Lucilla | |
dc.contributor.author | Farotti, Lucia | |
dc.contributor.author | Marizzoni, Moira | |
dc.contributor.author | D'Antonio, Fabrizia | |
dc.contributor.author | De Lena, Carlo | |
dc.contributor.author | Güntekin, Bahar | |
dc.contributor.author | Hanoğlu, Lütfü | |
dc.contributor.author | Yener, Görsev | |
dc.contributor.author | Emek Savaş, Derya Durusu | |
dc.contributor.author | Triggiani, Antonio Ivano | |
dc.contributor.author | Taylor, John Paul | |
dc.contributor.author | McKeith, Ian | |
dc.contributor.author | Stocchi, Fabrizio | |
dc.contributor.author | Vacca, Laura | |
dc.contributor.author | Hampel, Harald | |
dc.contributor.author | Frisoni, Giovanni B. | |
dc.contributor.author | Bonanni, Laura | |
dc.contributor.author | Babiloni, Claudio | |
dc.date.accessioned | 2020-11-13T07:22:48Z | |
dc.date.available | 2020-11-13T07:22:48Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Pascarelli, M. T., Del Percio, C., De Pandis, M. F., Ferri, R., Lizio, R., Noce, G. ... Babiloni, C. (2020). Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms. Clinical Neurophysiology, 131(11), 2716-2731. https://dx.doi.org/10.1016/j.clinph.2020.09.004 | en_US |
dc.identifier.issn | 1388-2457 | |
dc.identifier.issn | 1872-8952 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.clinph.2020.09.004 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/6027 | |
dc.description.abstract | Objective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms.Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources.Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB ``controls", the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p < 0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p < 0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p < 0.005).Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients.Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies. | en_US |
dc.description.sponsorship | Ministry of Health, Italy; H2020 Marie S. Curie ITN-ETN project; H2020-TWINN-2015 project | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Ireland Ltd | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Prodromal and Overt Dementia With Lewy Bodies (DLB) | en_US |
dc.subject | Mild Cognitive Impairment (MCI) | en_US |
dc.subject | Resting State Electroencephalographic (EEG) Rhythms | en_US |
dc.subject | Exact Low-Resolution Brain Electromagnetic Source Tomography (Eloreta) | en_US |
dc.subject | Visual Hallucinations | en_US |
dc.subject | Rapid Eye Movement Sleep Behavior Disorders (RBD) | en_US |
dc.title | Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Clinical Neurophysiology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-0860-0524 | en_US |
dc.authorid | 0000-0003-4292-5717 | en_US |
dc.identifier.volume | 131 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.startpage | 2716 | en_US |
dc.identifier.endpage | 2731 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.clinph.2020.09.004 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q1 | en_US |