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Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms

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Date

2020

Author

Pascarelli, Maria Teresa
Del Percio, Claudio
De Pandis, Maria Francesca
Ferri, Raffaele
Lizio, Roberta
Noce, Giuseppe
Lopez, Susanna
Rizzo, Marco
Soricelli, Andrea
Nobili, Flavio
Arnaldi, Dario
Fama, Francesco
Orzi, Francesco
Buttinelli, Carla
Giubilei, Franco
Salvetti, Marco
Cipollini, Virginia
Franciotti, Raffaella
Onofri, Marco
Fuhr, Peter
Gschwandtner, Ute
Ransmayr, Gerhard
Aarsland, Dag
Parnetti, Lucilla
Farotti, Lucia
Marizzoni, Moira
D'Antonio, Fabrizia
De Lena, Carlo
Güntekin, Bahar
Hanoğlu, Lütfü
Yener, Görsev
Emek Savaş, Derya Durusu
Triggiani, Antonio Ivano
Taylor, John Paul
McKeith, Ian
Stocchi, Fabrizio
Vacca, Laura
Hampel, Harald
Frisoni, Giovanni B.
Bonanni, Laura
Babiloni, Claudio

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Pascarelli, M. T., Del Percio, C., De Pandis, M. F., Ferri, R., Lizio, R., Noce, G. ... Babiloni, C. (2020). Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms. Clinical Neurophysiology, 131(11), 2716-2731. https://dx.doi.org/10.1016/j.clinph.2020.09.004

Abstract

Objective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms.Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources.Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB ``controls", the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p < 0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p < 0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p < 0.005).Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients.Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies.

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Source

Clinical Neurophysiology

Volume

131

Issue

11

URI

https://dx.doi.org/10.1016/j.clinph.2020.09.004
https://hdl.handle.net/20.500.12511/6027

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  • Makale Koleksiyonu [3082]
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  • PubMed İndeksli Yayınlar Koleksiyonu [3385]
  • Scopus İndeksli Yayınlar Koleksiyonu [5133]
  • WoS İndeksli Yayınlar Koleksiyonu [5391]



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