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dc.contributor.authorTosun, Fatma
dc.contributor.authorMihoğlugil, Feyyaz
dc.contributor.authorBeutler, John A. A.
dc.contributor.authorEroğlu Özkan, Esra
dc.contributor.authorMiski, Mahmut
dc.date.accessioned2020-09-03T06:54:51Z
dc.date.available2020-09-03T06:54:51Z
dc.date.issued2020en_US
dc.identifier.citationTosun, F., Mihoğlugil, F., Beutler, J. A. A., Eroğlu Özkan, E. ve Miski, M. (2020). Neopapillarine, an unusual coumarino-alkaloid from the root extract of neocryptodiscus papillaris with cytotoxic activity on renal cancer cells. Molecules, 25(13). https://dx.doi.org/10.3390/molecules25133040en_US
dc.identifier.issn1420-3049
dc.identifier.urihttps://dx.doi.org/10.3390/molecules25133040
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5765
dc.description.abstractSeveral simple and prenylated coumarin derivatives were isolated from the dichloromethane extract of the root of Neocryptodiscus papillaris based on moderate cytotoxic activity of the extract in COLO205, KM12 and MCF7 cancer cells. While the major prenylated furanocoumarin derivatives and osthol isolated from the dichloromethane extract were responsible for the activity in the colon and breast cancer cell lines, the 4'-acylated osthol derivatives including a novel coumarino-alkaloid; neopapillarine) demonstrated selective cytotoxic activity in A498 and UO31 renal cancer cell lines.en_US
dc.description.sponsorshipGazi University United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Cancer Institute (NCI)en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectNeocryptodiscus Papillarisen_US
dc.subjectApiaceaeen_US
dc.subjectSimple Coumarinsen_US
dc.subjectFuranocoumarinsen_US
dc.subjectPrenylated Coumarinsen_US
dc.subjectCoumarino-Alkaloiden_US
dc.subjectCytotoxic Activityen_US
dc.titleNeopapillarine, an unusual coumarino-alkaloid from the root extract of neocryptodiscus papillaris with cytotoxic activity on renal cancer cellsen_US
dc.typearticleen_US
dc.relation.ispartofMoleculesen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalıen_US
dc.authorid0000-0003-2533-5141en_US
dc.identifier.volume25en_US
dc.identifier.issue13en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3390/molecules25133040en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ1en_US


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