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dc.contributor.authorBademci, Refik
dc.contributor.authorErdoğan, Mümin Alper
dc.contributor.authorKara, Ali Yücel
dc.contributor.authorYiğittürk, Gürkan
dc.contributor.authorErbaş, Oytun
dc.date.accessioned2020-07-09T15:12:59Z
dc.date.available2020-07-09T15:12:59Z
dc.date.issued2020en_US
dc.identifier.citationBademci, R., Erdoğan, M. A., Kara, A. Y., Yiğittürk, G. ve Erbaş, O. (2020). Therapeutic effects of vitamin D on acetic acid-induced colitis in rats. Acta Cirurgica Brasileira, 35(4). http://dx.doi.org/10.1590/s0102-865020200040000004en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.urihttp://dx.doi.org/10.1590/s0102-865020200040000004
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5443
dc.description.abstractPurpose: To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. Methods: A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol 1 mu g/kg for 5 days. Results: Plasma tumor necrosis factor alpha, Pentraxin 3, and malondialdehyde levels were significantly lower in the calcitriol administered colitis group than in the standard colitis group (p<0.01). In the Calcitriol group, there was a significant histological improvement in hyperemia, hemorrhage and necrotic areas in the epithelium compared to the placebo group (p<0.000). Conclusion: The findings suggest that calcitriol may be an agent that could be used in acute colitis treatment.en_US
dc.language.isoengen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en*
dc.subjectCalcitriolen_US
dc.subjectColitisen_US
dc.subjectTumor Necrosis Factor-Alphaen_US
dc.subjectMalondialdehydeen_US
dc.subjectRatsen_US
dc.titleTherapeutic effects of vitamin D on acetic acid-induced colitis in ratsen_US
dc.typearticleen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.authorid0000-0001-9378-4438en_US
dc.identifier.volume35en_US
dc.identifier.issue4en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1590/s0102-865020200040000004en_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ3en_US


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