Therapeutic effects of vitamin D on acetic acid-induced colitis in rats
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CitationBademci, R., Erdoğan, M. A., Kara, A. Y., Yiğittürk, G. ve Erbaş, O. (2020). Therapeutic effects of vitamin D on acetic acid-induced colitis in rats. Acta Cirurgica Brasileira, 35(4). http://dx.doi.org/10.1590/s0102-865020200040000004
Purpose: To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. Methods: A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol 1 mu g/kg for 5 days. Results: Plasma tumor necrosis factor alpha, Pentraxin 3, and malondialdehyde levels were significantly lower in the calcitriol administered colitis group than in the standard colitis group (p<0.01). In the Calcitriol group, there was a significant histological improvement in hyperemia, hemorrhage and necrotic areas in the epithelium compared to the placebo group (p<0.000). Conclusion: The findings suggest that calcitriol may be an agent that could be used in acute colitis treatment.
SourceActa Cirurgica Brasileira
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