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dc.contributor.authorAnjomshoaa, Ida
dc.contributor.authorBriseno-Ruiz, Jessica
dc.contributor.authorDeeley, Kathleen
dc.contributor.authorPoletta, Fernardo
dc.contributor.authorMereb, Juan
dc.contributor.authorLeite, Aline
dc.contributor.authorBarreta, Priscila
dc.contributor.authorSilva, Thelma
dc.contributor.authorDizak, Piper
dc.contributor.authorRuff, Timothy
dc.contributor.authorPatır, Aslı
dc.contributor.authorKoruyucu, Mine
dc.contributor.authorAbbasoğlu, Zerrin
dc.contributor.authorCasado, Priscila
dc.contributor.authorBrown, Andrew
dc.contributor.authorZaky, Samer
dc.contributor.authorBayram, Merve
dc.contributor.authorKuechler, Erika
dc.contributor.authorCooper, Margaret
dc.contributor.authorLiu, Kai
dc.contributor.authorMarazita, Mary
dc.contributor.authorTanboğa, İlknur
dc.contributor.authorGranjeiro, Jose
dc.contributor.authorSeymen, Figen
dc.contributor.authorCastilla, Eduardo
dc.contributor.authorOrioli, Ieda
dc.contributor.authorSfeir, Charles
dc.contributor.authorOwyang, Hongjiao
dc.contributor.authorBuzalaf, Marilia
dc.contributor.authorVieira, Alexandre
dc.identifier.citationAnjomshoaa, I., Briseno-Ruiz, J., Deeley, K., Poletta, F., Mereb, J., Leite, A. ... Vieira, A. (2015). Aquaporin 5 interacts with fluoride and possibly protects against caries. Plos One, 10(12).
dc.description.abstractAquaporins (AQP) are water channel proteins and the genes coding for AQP2, AQP5, and AQP6 are clustered in 12q13. Since AQP5 is expressed in serous acinar cells of salivary glands, we investigated its involvement in caries. DNA samples from 1,383 individuals from six groups were studied. Genotypes of eight single nucleotide polymorphisms covering the aquaporin locus were tested for association with caries experience. Interaction with genes involved in enamel formation was tested. The association between enamel microhardness at baseline, after creation of artificial caries lesion, and after exposure to fluoride and the genetic markers in AQP5 was tested. Finally, AQP5 expression in human whole saliva, after exposure to fluoride in a mammary gland cell line, which is known to express AQP5, and in Wistar rats was also verified. Nominal associations were found between caries experience and markers in the AQP5 locus. Since these associations suggested that AQP5 may be inhibited by levels of fluoride in the drinking water that cause fluorosis, we showed that fluoride levels above optimal levels change AQP5 expression in humans, cell lines, and rats. We have shown that AQP5 is involved in the pathogenesis of caries and likely interacts with fluoride.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Dental & Craniofacial Researchen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsAttribution 4.0 International*
dc.titleAquaporin 5 interacts with fluoride and possibly protects against cariesen_US
dc.relation.ispartofPlos Oneen_US
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Ana Bilim Dalıen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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