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dc.contributor.authorGedik, Özge
dc.contributor.authorDoǧan, Remzi
dc.contributor.authorBabademez, Mehmet Ali
dc.contributor.authorKarataş, Ersin
dc.contributor.authorAydın, Mehmet Şerif
dc.contributor.authorKoçyiǧit, Abdurrahim
dc.contributor.authorEşrefoǧlu, Mukaddes
dc.contributor.authorÖzturan, Orhan
dc.date.accessioned2020-04-27T11:55:45Z
dc.date.available2020-04-27T11:55:45Z
dc.date.issued2020en_US
dc.identifier.citationGedik, Ö., Doǧan, R., Babademez, M. A., Karataş, E., Aydın, M. Ş., Koçyiǧit, A. ... Özturan, O. (2020). Therapeutic effects of metformin for noise induced hearing loss. American Journal of Otolaryngology, 41(1). https://dx.doi.org/10.1016/j.amjoto.2019.102328en_US
dc.identifier.issn0196-0709
dc.identifier.issn1532-818X
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5205
dc.identifier.urihttps://dx.doi.org/10.1016/j.amjoto.2019.102328
dc.description.abstractObjective: This study aimed to investigate the healing effect of metformin on noise induced hearing loss (NIHL) by measuring audiological, biochemical and histological parameters.Materials and methods: 32 rats were divided into four groups (Group 1: Noise, Group 2: Noise + Metformin, Grup 3: Metformin, Grup 4: Control). Broadband noise was applied to Group 1 and Group 2 after basal measurements. Measuring audiological (distortion product otoacoustic emission (DPOAE) and Auditory Brainstem Response (ABR)), biochemical (total antioxidant status (TAS), total oxidant status (TOS), oxidative status index (OSI), DNA damage, IL-1 beta, IL-6, TNF alfa, HSF-1 and COX-2) and histological parameters.Results: Group 2 had significant decreases in ABR thresholds on day 7 and day 14 compared to day 1. DPOAE values of Group 2 on the 7th and 14th days were significantly higher than the post-noise levels. DNA damage, TOS and OSI values of Group 1 were significantly higher than the other groups. The Cox-2 value of Group 1 was higher than all other groups. The HSF-1 value of Group 2 was significantly higher than that of Group 1. In terms of IL-1 Beta, IL-6 and TNF-alpha values, there was no significant difference between groups 2, 3 and 4 and these values were significantly lower than group 1. In histopathological results of our study, no significant difference was found between the groups being exposed to noise and the control group.Conclusion: This study showed that early period of Metformin treatment has therapeutic effect on NIHL.en_US
dc.language.isoengen_US
dc.publisherW.B. Saundersen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectABRen_US
dc.subjectDNA Damageen_US
dc.subjectDPOAEen_US
dc.subjectNoise-Induced Hearing Lossen_US
dc.subjectMetforminen_US
dc.subjectRaten_US
dc.titleTherapeutic effects of metformin for noise induced hearing lossen_US
dc.typearticleen_US
dc.relation.journalAmerican Journal of Otolaryngologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0002-6393-1465en_US
dc.identifier.volume41en_US
dc.identifier.issue1en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.amjoto.2019.102328en_US


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