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dc.contributor.authorYuluǧ, Burak
dc.contributor.authorSaatçi, Özlem
dc.contributor.authorIşıklar, Aysun
dc.contributor.authorHanoǧlu, Lütfü
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorÇankaya, Şeyda
dc.contributor.authorÇankaya, Barış
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned2020-04-21T06:37:29Z
dc.date.available2020-04-21T06:37:29Z
dc.date.issued2020en_US
dc.identifier.citationYuluǧ, B., Saatçi, Ö., Işıklar, A., Hanoǧlu, L., Kılıç, Ü., Ozansoy, M. ... Kılıç, E. (2020). The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons. Endocrine Metabolic & Immune Disorders-Drug Targets, 20(2), 198-212. https://dx.doi.org/10.2174/1871530319666190614121738en_US
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5182
dc.identifier.urihttps://dx.doi.org/10.2174/1871530319666190614121738
dc.description.abstractBackground and Aim: Recent data have shown that olfactory dysfunction is strongly related to Alzheimer's Disease (AD) that is often preceded by olfactory deficits suggesting that olfactory dysfunction might represent an early indicator of future cognitive in prediabetes.Methods: We have applied to a group of normal (n=15), prediabetic (n=16) and type 2 diabetic outpatients (n=15) olfactory testing, 1.5-T MRI scanner and detailed cognitive evaluation including the standard Mini-Mental State Examination (MMSE) form, Short Blessed Test (SBT), Letter Fluency Test (LFT) and the category fluency test with animal, Fruit and Vegetable Naming (CFT).Results: We have shown that Odour Threshold (OT), Discrimination (OD), and Identification (OI) scores and most cognitive test results were significantly different in the prediabetes and diabetes group compared to those in the control group. OD and OT were significantly different between the prediabetes and diabetes group, although the cognitive test results were only significantly different in the pre-diabetes and diabetes group compared to those in the control group. In evaluating the association between OI, OT, OD scores and specific cognitive tests, we have found, that impaired olfactory identification was the only parameter that correlated significantly with the SBT both in the pre-diabetes and diabetes group. Although spot glucose values were only correlated with OT, HbA1c levels were correlated with OT, OD, and OI, as well as results of the letter fluency test suggesting that HbA1c levels rather than the spot glucose values play a critical role in specific cognitive dysfunction.Conclusion: To the best of our knowledge, this is the first prospective study to demonstrate a strong association between olfactory dysfunction and specific memory impairment in a population with pre-diabetes and diabetes suggesting that impaired olfactory identification might play an important role as a specific predictor of memory decline.en_US
dc.language.isoengen_US
dc.publisherBentham Science Publ Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOlfactionen_US
dc.subjectCognitionen_US
dc.subjectPrediabetesen_US
dc.subjectDiabetesen_US
dc.subjectOlfactory Memoryen_US
dc.subjectMemory Dysfunctionen_US
dc.titleThe association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic personsen_US
dc.typearticleen_US
dc.relation.ispartofEndocrine Metabolic & Immune Disorders-Drug Targetsen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-9704-6173en_US
dc.authorid0000-0003-4292-5717en_US
dc.authorid0000-0002-1079-8832en_US
dc.authorid0000-0001-6494-8923en_US
dc.identifier.volume20en_US
dc.identifier.issue2en_US
dc.identifier.startpage198en_US
dc.identifier.endpage212en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.2174/1871530319666190614121738en_US
dc.identifier.wosqualityQ3en_US
dc.identifier.scopusqualityQ3en_US


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