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dc.contributor.authorAklan, İltan
dc.contributor.authorSayar Atasoy, Nilufer
dc.contributor.authorYavuz, Yavuz
dc.contributor.authorAteş, Tayfun
dc.contributor.authorÇoban, İlknur
dc.contributor.authorKöksalar, Fulya
dc.contributor.authorFiliz, Gizem
dc.contributor.authorTopçu, İskalen Cansu
dc.contributor.authorÖncül, Merve
dc.contributor.authorDilsiz, Pelin
dc.contributor.authorCebecioğlu, Utku
dc.contributor.authorAlp, Muhammed İkbal
dc.contributor.authorYılmaz, Bayram
dc.contributor.authorDavis, Deborah R.
dc.contributor.authorHajdukiewicz, Karolina
dc.contributor.authorSaito, Kenji
dc.contributor.authorKonopka, Witold
dc.contributor.authorCui, Huxing
dc.contributor.authorAtasoy, Deniz
dc.date.accessioned2020-04-15T09:53:14Z
dc.date.available2020-04-15T09:53:14Z
dc.date.issued2020en_US
dc.identifier.citationAklan, İ., Sayar Atasoy, N., Yavuz, Y., Ateş, T., Çoban, İ., Köksalar, F. ... Atasoy, D. (2020). NTS catecholamine neurons mediate hypoglycemic hunger via medial hypothalamic feeding pathways. Cell Metabolism, 31(2), 313-326, e1-e5. https://dx.doi.org/10.1016/j.cmet.2019.11.016en_US
dc.identifier.issn1550-4131
dc.identifier.issn1932-7420
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5121
dc.identifier.urihttps://dx.doi.org/10.1016/j.cmet.2019.11.016
dc.description.abstractGlucose is the essential energy source for the brain, whose deficit, triggered by energy deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral defense against hypoglycemia; however, the central pathways involved are not well understood. Here, we describe a glucoprivic feeding pathway by tyrosine hydroxylase (TH)-expressing neurons from nucleus of solitary tract (NTS), which project densely to the hypothalamus and elicit feeding through bidirectional adrenergic modulation of agouti-related peptide (AgRP)- and proopiomelanocortin (POMC)-expressing neurons. Acute chemogenetic inhibition of arcuate nucleus (ARC)-projecting NTSTH neurons or their target, AgRP neurons, impaired glucoprivic feeding induced by 2-Deoxy-D-glucose (2DG) injection. Neuroanatomical tracing results suggested that ARC-projecting orexigenic NTSTH neurons are largely distinct from neighboring catecholamine neurons projecting to parabrachial nucleus (PBN) that promotes satiety. Collectively, we describe a circuit organization in which an ascending pathway from brainstem stimulates appetite through key hunger neurons in the hypothalamus in response to hypoglycemia.en_US
dc.description.sponsorshipEMBO IGen_US
dc.description.sponsorshipFOEDRCen_US
dc.language.isoengen_US
dc.publisherCell Pressen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectNTSen_US
dc.subjectCatecholamine Neuronsen_US
dc.subjectMedial Hypothalamicen_US
dc.titleNTS catecholamine neurons mediate hypoglycemic hunger via medial hypothalamic feeding pathwaysen_US
dc.typearticleen_US
dc.relation.ispartofCell Metabolismen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0002-9520-6903en_US
dc.authorid0000-0003-2075-7724en_US
dc.identifier.volume31en_US
dc.identifier.issue2en_US
dc.identifier.startpage313en_US
dc.identifier.endpage326, e1-e5en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.cmet.2019.11.016en_US
dc.identifier.wosqualityQ1en_US
dc.identifier.scopusqualityQ1en_US


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