dc.contributor.author | Aklan, İltan | |
dc.contributor.author | Sayar Atasoy, Nilufer | |
dc.contributor.author | Yavuz, Yavuz | |
dc.contributor.author | Ateş, Tayfun | |
dc.contributor.author | Çoban, İlknur | |
dc.contributor.author | Köksalar, Fulya | |
dc.contributor.author | Filiz, Gizem | |
dc.contributor.author | Topçu, İskalen Cansu | |
dc.contributor.author | Öncül, Merve | |
dc.contributor.author | Dilsiz, Pelin | |
dc.contributor.author | Cebecioğlu, Utku | |
dc.contributor.author | Alp, Muhammed İkbal | |
dc.contributor.author | Yılmaz, Bayram | |
dc.contributor.author | Davis, Deborah R. | |
dc.contributor.author | Hajdukiewicz, Karolina | |
dc.contributor.author | Saito, Kenji | |
dc.contributor.author | Konopka, Witold | |
dc.contributor.author | Cui, Huxing | |
dc.contributor.author | Atasoy, Deniz | |
dc.date.accessioned | 2020-04-15T09:53:14Z | |
dc.date.available | 2020-04-15T09:53:14Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Aklan, İ., Sayar Atasoy, N., Yavuz, Y., Ateş, T., Çoban, İ., Köksalar, F. ... Atasoy, D. (2020). NTS catecholamine neurons mediate hypoglycemic hunger via medial hypothalamic feeding pathways. Cell Metabolism, 31(2), 313-326, e1-e5.
https://dx.doi.org/10.1016/j.cmet.2019.11.016 | en_US |
dc.identifier.issn | 1550-4131 | |
dc.identifier.issn | 1932-7420 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/5121 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.cmet.2019.11.016 | |
dc.description.abstract | Glucose is the essential energy source for the brain, whose deficit, triggered by energy deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral defense against hypoglycemia; however, the central pathways involved are not well understood. Here, we describe a glucoprivic feeding pathway by tyrosine hydroxylase (TH)-expressing neurons from nucleus of solitary tract (NTS), which project densely to the hypothalamus and elicit feeding through bidirectional adrenergic modulation of agouti-related peptide (AgRP)- and proopiomelanocortin (POMC)-expressing neurons. Acute chemogenetic inhibition of arcuate nucleus (ARC)-projecting NTSTH neurons or their target, AgRP neurons, impaired glucoprivic feeding induced by 2-Deoxy-D-glucose (2DG) injection. Neuroanatomical tracing results suggested that ARC-projecting orexigenic NTSTH neurons are largely distinct from neighboring catecholamine neurons projecting to parabrachial nucleus (PBN) that promotes satiety. Collectively, we describe a circuit organization in which an ascending pathway from brainstem stimulates appetite through key hunger neurons in the hypothalamus in response to hypoglycemia. | en_US |
dc.description.sponsorship | EMBO IG | en_US |
dc.description.sponsorship | FOEDRC | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Cell Press | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | NTS | en_US |
dc.subject | Catecholamine Neurons | en_US |
dc.subject | Medial Hypothalamic | en_US |
dc.title | NTS catecholamine neurons mediate hypoglycemic hunger via medial hypothalamic feeding pathways | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Cell Metabolism | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.authorid | 0000-0002-9520-6903 | en_US |
dc.authorid | 0000-0003-2075-7724 | en_US |
dc.identifier.volume | 31 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 313 | en_US |
dc.identifier.endpage | 326, e1-e5 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.cmet.2019.11.016 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |