NTS catecholamine neurons mediate hypoglycemic hunger via medial hypothalamic feeding pathways
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info:eu-repo/semantics/embargoedAccessTarih
2020Yazar
Aklan, İltanSayar Atasoy, Nilufer
Yavuz, Yavuz
Ateş, Tayfun
Çoban, İlknur
Köksalar, Fulya
Filiz, Gizem
Topçu, İskalen Cansu
Öncül, Merve
Dilsiz, Pelin
Cebecioğlu, Utku
Alp, Muhammed İkbal
Yılmaz, Bayram
Davis, Deborah R.
Hajdukiewicz, Karolina
Saito, Kenji
Konopka, Witold
Cui, Huxing
Atasoy, Deniz
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Aklan, İ., Sayar Atasoy, N., Yavuz, Y., Ateş, T., Çoban, İ., Köksalar, F. ... Atasoy, D. (2020). NTS catecholamine neurons mediate hypoglycemic hunger via medial hypothalamic feeding pathways. Cell Metabolism, 31(2), 313-326, e1-e5. https://dx.doi.org/10.1016/j.cmet.2019.11.016Özet
Glucose is the essential energy source for the brain, whose deficit, triggered by energy deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral defense against hypoglycemia; however, the central pathways involved are not well understood. Here, we describe a glucoprivic feeding pathway by tyrosine hydroxylase (TH)-expressing neurons from nucleus of solitary tract (NTS), which project densely to the hypothalamus and elicit feeding through bidirectional adrenergic modulation of agouti-related peptide (AgRP)- and proopiomelanocortin (POMC)-expressing neurons. Acute chemogenetic inhibition of arcuate nucleus (ARC)-projecting NTSTH neurons or their target, AgRP neurons, impaired glucoprivic feeding induced by 2-Deoxy-D-glucose (2DG) injection. Neuroanatomical tracing results suggested that ARC-projecting orexigenic NTSTH neurons are largely distinct from neighboring catecholamine neurons projecting to parabrachial nucleus (PBN) that promotes satiety. Collectively, we describe a circuit organization in which an ascending pathway from brainstem stimulates appetite through key hunger neurons in the hypothalamus in response to hypoglycemia.
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Cell MetabolismCilt
31Sayı
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