Yazar "Kılıç, Ülkan" için WoS İndeksli Yayınlar Koleksiyonu listeleme
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Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice
Çağlayan, Berrak; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Yalçın, Esra; Beker, Merve; Keleştemur, Taha; Sertel, Elif; Öztürk, Gürkan; Kılıç, Ülkan; Şahin, Fikrettin; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2017)Conflicting data in the literature about the function of P2X7R in survival following ischemia necessitates the conductance of in-depth studies. To investigate the impacts of activation vs inhibition of the receptor on ... -
Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival
Yalçın, Esra; Beker, Mustafa Çağlar; Türkseven, Şeyma; Çağlayan, Berrak; Gürel, Büşra; Kılıç, Ülkan; Çağlayan, Ahmet Burak; Kalkan, Rabia; Baykal, Ahmet Tarık; Keleştemur, Taha; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2019)Indolamine melatonin structurally resembles non-covalent proteasome inhibitors; however, the role of ubiquitin proteasome system (UPS) in neuronal survival and how melatonin carries out UPS inhibition remain largely unknown. ... -
GAS6 intron 8 c.834+7G > A gene polymorphism in diabetic nephropathy
Erkoç, Reha; Çıkrıkçıoğlu, Mehmet Ali; Aintab, Emre; Erek-Toprak, Aybala; Kılıç, Ülkan; Gök, Özlem; Yasin Çetin, Ayşe İrem; Zorlu, Mehmet; Kıskaç, Muharrem; Çakırca, Mustafa; Erkal, Sena Nur; İsen, Hayati Can; Karatoprak, Cumali (Taylor and Francis, 2015)Background - Aim: In animal experiments, growth arrest-specific 6 (Gas6) protein plays a key role in the development of mesangial cell and glomerular hypertrophy in the early phase of diabetic nephropathy, and diabetic ... -
HMG-CoA reductase inhibition promotes neurological recovery, peri-lesional tissue remodeling, and contralesional pyramidal tract plasticity after focal cerebral ischemia
Kılıç, Ertuğrul; Reitmeir, Raluca; Kılıç, Ülkan; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Kelestemur, Taha; Ethemoğlu, Muhsine Sinem; Öztürk, Gürkan; Hermann, Dirk M. (Frontiers Research Foundation, 2014)3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are widely used for secondary stroke prevention. Besides their lipid-lowering activity, pleiotropic effects on neuronal survival, angiogenesis, and ... -
HMG-CoA reductase inhibitor rosuvastatin improves abnormal brain electrical activity via mechanisms involving eNOS
Şeker, Fatma Burcu; Kılıç, Ülkan; Çaǧlayan, Berrak; Ethemoğlu, Muhsine Sinem; Çağlayan, Ahmet Burak; Ekimci, Nur; Demirci, Selami; Doǧan, Ayşegül; Öztezcan, Serdar; Şahin, Fikrettin; Yılmaz, Bayram; Kılıç, Ertuğrul (Elsevier, 2015)Apart from its repressing effect on plasma lipid levels, 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors exert neuroprotective functions in animal models of neurodegenerative disorders. In view of ... -
Inflammatory cytokines are in action: Brain plasticity and recovery after brain ischemia due to delayed melatonin administration
Kılıç, Ülkan; Elibol, Birsen; Beker, Merve; Altuğ Tasa, Burcugül; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Yılmaz, Bayram; Kılıç, Ertuğrul (W.B. Saunders, 2021)Objectives: Post-ischemic inflammation leads to apoptosis as an indirect cause of functional disabilities after the stroke. Melatonin may be a good candidate for the stroke recovery because of its anti-inflammatory effects. ... -
Integrin α5β1 mediated cellular reorganization in human mesenchymal stem cells during neuronal differentiation
Karakaş, Nihal; Kılıç, Ülkan (International Institute of Anticancer Research, 2021)Background/Aim: Mesenchymal stem cells (MSCs) have been widely used for yielding neurons in culture to study nervous system pathologies and develop regenerative approaches. In this study, cellular rearrangements of human ... -
Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival
Beker, Mustafa Çağlar; Çağlayan, Berrak; Çağlayan, Ahmet Burak; Kelestemur, Taha; Yalçın, Esra; Çağlayan, Aysun; Kılıç, Ülkan; Baykal, Ahmet Tarık; Reiter, Russel J.; Kılıç, Ertuğrul (Nature Publishing Group, 2019)The circadian rhythm is driven by a master clock within the suprachiasmatic nucleus which regulates the rhythmic secretion of melatonin. Bmal1 coordinates the rhythmic expression of transcriptome and regulates biological ... -
Investigation of possible effect of carnosic acid (CA) on combined exposure to bisphenol a (BPA) and diethyl hexyl phthalate (DEHP)
Özdatlı, Şükran; Kalkan, Rasime; Hatimoğlu, M.; Kılıç, Ülkan; Aydın, Ahmet (Elsevier Ireland Ltd, 2018)DEHP and BPA, the main components of plastic products, are the important endocrine-disrupting chemicals which can mimic or disrupt the actions of estrogen by inhibiting normal functions of the body. Because of this widespread ... -
Melatonin affects the release of exosomes and tau-content in in vitro amyloid-beta toxicity model
Ozansoy, Mehmet; Ozansoy, Muzaffer Beyza; Yuluğ, Burak; Çankaya, Şeyda; Kılıç, Ertuğrul; Göktekin, Şule; Kılıç, Ülkan (Elsevier Science Ltd., 2020)Background: Recent studies have been revealed that oxidative damage is the main cause of aging and age-related neurodegenerative diseases like Alzheimer's disease (AD). Melatonin is secreted from the pineal gland and its ... -
Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway
Kılıç, Ülkan; Kılıç, Ertuğrul; Tuzcu, Zeynep; Tuzcu, Mehmet; Özercan, İbrahim; Yılmaz, Ökkeş; Şahin, Fikrettin; Şahin, Kazım (Biomed Central Ltd, 2013)Background: Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited ... -
Minocycline increases in-vitro cortical neuronal cell survival after laser induced axotomy
Yuluğ, Burak; Ozansoy, Mehmet; Alökten, Merve; Çetin Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Hanoğlu, Lütfü; Kılıç, Ülkan; Kılıç, Ertuğrul (2020)Antibiotic therapies targeting multiple regenerative mechanisms have the potential for neuroprotective effects, but the diversity of experimental strategies and analyses of non-standardised therapeutic trials are challenging. ...