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An improved platform for cultured neuronal network electrophysiology: Multichannel optogenetics integrated with MEAs
(Springer, 2022)
Cultured neuronal networks (CNNs) are powerful tools for studying how neuronal representation and adaptation emerge in networks of controlled populations of neurons. To ensure the interaction of a CNN and an artificial ...
Phosphodiesterase 10A is a critical target for neuroprotection in a mouse model of ischemic stroke
(Springer, 2022)
Phosphodiesterase 10A (PDE10A) hydrolyzes adenosine 3 ',5 '-cyclic monophosphate (cAMP) and guanosine 3 ',5 '-cyclic monophosphate (cGMP). It is highly expressed in the striatum. Recent evidence implied that PDE10A may be ...
Resting state alpha electroencephalographic rhythms are affected by sex in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment: A retrospective and exploratory study
(Oxford University Press Inc, 2022)
In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors ...
Comparison of 3 cell-free matrix scaffolds used to treat osteochondral lesions in a rabbit model
(SAGE Publications Inc., 2022)
Background: Various cell-free scaffolds are already in use for the treatment of osteochondral defects (OCDs); however, a gold standard material has not yet been defined. Purpose: This study compared the macroscopic, ...
The association of oxidative stress and DNA damage with XRCC1 and XRCC3 polymorphisms in radiology technicians
(SAGE Publications Ltd, 2022)
Ionizing radiation has widespread use in medicine in the diagnosis and treatment of many medical conditions. Radiology technicians are one group that is occupationally exposed to low doses of radiation. There are questions ...
Delayed therapeutic administration of melatonin enhances neuronal survival through AKT and MAPK signaling pathways following focal brain ischemia in mice
(Springer Nature, 2022)
Melatonin has a role in the cell survival signaling pathways as a candidate for secondary stroke prevention. Therefore, in the present study, the coordination of ipsilateral and contralateral hemispheres to evaluate delayed ...
Multiple sclerosis biomarker candidates revealed by cell-type-specific interactome analysis
(Mary Ann Liebert, 2022)
Multiple sclerosis (MS) is a demyelinating disorder that affects multiple regions of the central nervous system such as the brain, spinal cord, and optic nerves. Susceptibility to MS, as well as disease progression rates, ...
New bone-generative effect of Salvia officinalis L. in the expanded midpalatal suture An in vivo and in vitro study
(Urban & Vogel, 2022)
Purpose The aims of this study were to evaluate the effects of systemic administration of Salvia officinalis Linnaeus (L.) leaf extract on new bone formation in the expanded premaxillary suture in rats in vivo and to examine ...
Inhibition of SARS-CoV-2 main protease: A repurposing study that targets the dimer interface of the protein
(Taylor and Francis Ltd., 2022)
Coronavirus disease-2019 (COVID-19) was firstly reported in Wuhan, China, towards the end of 2019, and emerged as a pandemic. The spread and lethality rates of the COVID-19 have ignited studies that focus on the development ...
Human macrophages directly modulate iPSC-derived cardiomyocytes at healthy state and congenital arrhythmia model in vitro
(Springer Heidelberg, 2022)
The electrophysiological regulation of cardiomyocytes (CMs) by the cardiac macrophages (M Phi s) has been recently described as an unconventional role of M Phi s in the murine heart. Investigating the molecular and ...