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Combination therapy with thrombolysis
(Springer International Publishing AG, 2017)
Thrombolysis is the most effective treatment for acute ischemic stroke representing the basic therapeutic standard in the western world. Novel drug treatments are therefore unlikely to be developed as stand-alone approaches ...
Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice
(Elsevier Sciences Bv, 2017)
Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased ...