Yazar "Kerman, Bilal Ersen" için Makale Koleksiyonu listeleme
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Combined segmentation and classificationbased approach to automated analysis of biomedical signals obtained from calcium imaging
Dursun, Gizem; Bijelić, Dunja; Ayşit, Neşe; Kurt Vatandaşlar, Burcu; Radenović, Lidija; Çapar, Abdulkerim; Kerman, Bilal Ersen; Andjus, Pavle R.; Korenić, Andrej; Özkaya, Ufuk (Public Library of Science, 2023)Automated screening systems in conjunction with machine learning-based methods are becoming an essential part of the healthcare systems for assisting in disease diagnosis. Moreover, manually annotating data and hand-crafting ... -
Differentiation of inflammation-responsive astrocytes from glial progenitors generated from human induced pluripotent stem cells
Santos, Renata; Vadodaria, Krishna C.; Jaeger, Baptiste N.; Mei, Arianna; Lefcochilos-Fogelquist, Sabrina; Mendes, Ana P. D.; Erikson, Galina; Shokhirev, Maxim; Randolph-Moore, Lynne; Fredlender, Callie; Dave, Sonia; Oefner, Ruth; Fitzpatrick, Conor; Pena, Monique; Barron, Jerika J.; Ku, Manching; Denli, Ahmet M.; Kerman, Bilal Ersen; Charnay, Patrick; Kelsoe, John R.; Marchetto, Maria C.; Gage, Fred H. (Cell Press, 2017)Astrocyte dysfunction and neuroinflammation are detrimental features in multiple pathologies of the CNS. Therefore, the development of methods that produce functional human astrocytes represents an advance in the study of ... -
In vitro myelin formation using embryonic stem cells
Kerman, Bilal Ersen; Kim, Hyung-joon; Padmanabhan, Krishnan; Mei, Arianna; Georges, Shereen; Joens, Matthew; Fitzpatrick, James; Jappelli, Roberto; Chandross, Karen; August, Paul; Gage, Fred (Company of Biologists, 2015)Myelination in the central nervous system is the process by which oligodendrocytes form myelin sheaths around the axons of neurons. Myelination enables neurons to transmit information more quickly and more efficiently and ... -
Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination
Kerman, Bilal Ersen; Genoud, Stephane; Kurt Vatandaşlar, Burcu; Denli, Ahmet Murat; Ghosh, Shereen Georges; Xu, Xiangdong; Yeo, Gene W.; Aimone, James Bradley; Gage, Fred H. (American Society for Biochemistry and Molecular Biology Inc, 2020)Disorders that disrupt myelin formation during development or in adulthood, such as multiple sclerosis and peripheral neuropathies, lead to severe pathologies, illustrating myelin's crucial role in normal neural functioning. ... -
A multi-spectral myelin annotation tool for machine learning based myelin quantification [version 1; peer review: 1 not approved]
Çapar, Abdulkerim; Çimen Yetiş, Sibel; Aladağ, Zeynep; Ekinci, Dursun Ali; Ayten, Umut Engin; Kerman, Bilal Ersen; Töreyin, Behçet Uğur (F1000 Research Ltd, 2021)Myelin is an essential component of the nervous system and myelin damage causes demyelination diseases. Myelin is a sheet of oligodendrocyte membrane wrapped around the neuronal axon. In the fluorescent images, experts ... -
Multiple sclerosis biomarker candidates revealed by cell-type-specific interactome analysis
Yurduseven, Kübra; Babal, Yigit Koray; Çelik, Eşref; Kerman, Bilal Ersen; Aksan Kurnaz, Işıl (Mary Ann Liebert, 2022)Multiple sclerosis (MS) is a demyelinating disorder that affects multiple regions of the central nervous system such as the brain, spinal cord, and optic nerves. Susceptibility to MS, as well as disease progression rates, ... -
Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice
Kılıç, Ülkan; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Günal, Mehmet Yalçın; Çağlayan, Berrak; Yalçın, Esra; Keleştemur, Taha; Gündoğdu, Reyhan Zeynep; Yuluğ, Burak; Yılmaz, Bayram; Kerman, Bilal Ersen; Kılıç, Ertuğrul (Elsevier Sciences Bv, 2017)Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased ... -
Species-specific maturation profiles of human, chimpanzee and bonobo neural cells
Marchetto, Maria Carolina; Hrvoj-Mihic, Branka; Kerman, Bilal Ersen; Yu, Diana X.; Vadodaria, Krishna C.; Linker, Sara B.; Narvaiza, Inigo; Santos, Renata; Denli, Ahmet M.; Mendes, Ana P. D.; Oefner, Ruth; Cook, Jonathan; McHenry, Lauren; Grasmick, Jaeson M.; Heard, Kelly; Fredlender, Callie; Randolph-Moore, Lynne; Kshirsagar, Rijul; Xenitopoulos, Rea; Chou, Grace; Hah, Nasun; Muotri, Alysson R.; Padmanabhan, Krishnan; Semendeferi, Katerina; Gage, Fred H. (Elife Sciences Publications Ltd, 2019)Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often ... -
Two phases of macrophages: Inducing maturation and death of oligodendrocytes in vitro co-culture
Aydınlı, Fatmagül İlayda; Er, Sezgin; Kerman, Bilal Ersen (Elsevier B.V., 2022)Background: The plasticity of macrophages in the immune response is a dynamic situation dependent on external stimuli. The activation of macrophages both has beneficial and detrimental effects on mature oligodendrocytes ... -
α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy
Ettle, Benjamin; Kerman, Bilal Ersen; Valera-Martin, Elvira; Gillmann, Clarissa; Schlachetzki, Johannes Carolus Magnus; Reiprich, Simone; Büttner, Christian; Ekici, Arif Bülent; Reis, André; Wegner, Michael M.; Baüerle, Tobias J.; Riemenschneider, Markus Johannes; Masliah, Eliezer; Gage, Fred H.; Winkler, Jürgen (Springer, 2016)Multiple system atrophy (MSA) is a rare atypical parkinsonian disorder characterized by a rapidly progressing clinical course and at present without any efficient therapy. Neuropathologically, myelin loss and neurodegeneration ...