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Male infertility, azoozpermia and cryptozoospermia incidence among three infertility clinics in Turkey
(AVES İbrahim Kara, 2018)Objective: Semen parameters are directly correlated with the infertility of the male. Incidence rates of male factor infertility, azoospermia and cryptozoospermia differ according to many factors such as geographic region, ... -
MCH neuron activity ıs sufficient for reward and reinforces feeding
(Karger, 2020)Background: Melanin-concentrating hormone (MCH)-expressing neurons have been implicated in regulation of energy homeostasis and reward, yet the role of their electrical activity in short-term appetite and reward modulation ... -
Mechanistic insight into impact of phosphorylation on the enzymatic steps of farnesyltransferase
(Wiley, 2022)Farnesyltransferase (FTase) is a heterodimeric enzyme, which catalyzes covalent attachment of the farnesyl group to target proteins, thus coordinating their trafficking in the cell. FTase has been demonstrated to be highly ... -
Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer
(Elsevier B.V., 2022)Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies ... -
Melatonin affects the release of exosomes and tau-content in in vitro amyloid-beta toxicity model
(Elsevier Science Ltd., 2020)Background: Recent studies have been revealed that oxidative damage is the main cause of aging and age-related neurodegenerative diseases like Alzheimer's disease (AD). Melatonin is secreted from the pineal gland and its ... -
Mesenchymal stem cell-based COVID-19 therapy: Bioengineering perspectives
(MDPI, 2022)The novel pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Mesenchymal stem cells (MSCs) are currently utilized in clinics for pulmonary inflammatory ... -
Metaproteogenomic analysis of saliva samples from Parkinson's disease patients with cognitive impairment
(Nature Portfolio, 2023)Cognitive impairment (CI) is very common in patients with Parkinson's Disease (PD) and progressively develops on a spectrum from mild cognitive impairment (PD-MCI) to full dementia (PDD). Identification of PD patients at ... -
Microbial composition of Kombucha determined using amplicon sequencing and shotgun metagenomics
(Wiley, 2020)Kombucha, a fermented tea generated from the co-culture of yeasts and bacteria, has gained worldwide popularity in recent years due to its potential benefits to human health. As a result, many studies have attempted to ... -
Microbiome and longevity: High abundance of longevity-linked muribaculaceae in the gut of the long-living rodentspalax leucodon
(Mary Ann Liebert Inc, 2020)With a world population living longer as well as marked disparities in life expectancy, understanding the determinants of longevity is one of the priority research agendas in 21st century life sciences. To this end, the ... -
Microfluidics and nanoparticles based amperometric biosensor for the detection of cyanobacteria (Planktothrix agardhii NIVA-CYA 116) DNA
(Elsevier, 2015)Some of the cyanobacteria produce protease inhibitor oligopeptides such as cyanopeptolins and cause drinking water contamination; hence, their detection has great importance to monitor the well-being of water sources that ... -
Minocycline increases in-vitro cortical neuronal cell survival after laser induced axotomy
(2020)Antibiotic therapies targeting multiple regenerative mechanisms have the potential for neuroprotective effects, but the diversity of experimental strategies and analyses of non-standardised therapeutic trials are challenging. ... -
Modeling the end date of COVID-19 pandemic
(Türkiye Klinikleri, 2020)Objective:As we have been living through COVID-19 pandemic for more than 5 months with its all detrimental im-pacts on our economic, social, and individual lives, developing models that will accurately inform us about the ... -
The modulation of delta responses in the interaction of brightness and emotion
(Elsevier Science Bv, 2017)The modulation of delta oscillations (0.5-3.5 Hz) by emotional stimuli is reported. Physical attributes such as color, brightness and spatial frequency of emotional visual stimuli have crucial effect on the perception of ... -
Modulation of oxidative stress and Ca2+ mobilization through TRPM2 channels in rat dorsal root ganglion neuron by Hypericum perforatum
(Pergamon-Elsevier Science Ltd., 2014)A main component of St. John's Wort (Hypericum perforatum, HP) is hyperforin which has antioxidant properties in dorsal root ganglion (DRG) neurons, due to its ability to modulate NADPH oxidase and protein kinase C. Recent ... -
Morphology-dependent immunomodulatory coating of hydroxyapatite/PEO for magnesium-based bone implants
(2023)One of the most critical issues concerning orthopedic implants is the risk of chronic inflammation, which poses a threat to the bone healing process. Osteo-immunomodulation plays a pivotal role in implant technology by ... -
Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination
(American Society for Biochemistry and Molecular Biology Inc, 2020)Disorders that disrupt myelin formation during development or in adulthood, such as multiple sclerosis and peripheral neuropathies, lead to severe pathologies, illustrating myelin's crucial role in normal neural functioning. ... -
A multi-spectral myelin annotation tool for machine learning based myelin quantification [version 1; peer review: 1 not approved]
(F1000 Research Ltd, 2021)Myelin is an essential component of the nervous system and myelin damage causes demyelination diseases. Myelin is a sheet of oligodendrocyte membrane wrapped around the neuronal axon. In the fluorescent images, experts ... -
The multifactorial role of pre-supplementary motor area stimulation in the freezing of gait: An alternative strategy to the classical drug-Target approach
(Bentham Science Publishers, 2022)Introduction: The pre-supplementary motor area (Pre-SMA) plays a pivotal role in the control of voluntary motor control and freezing of gait (FOG) pathophysiological mechanism. Here, we aimed to modulate if the pre-SMA ... -
Multiple sclerosis biomarker candidates revealed by cell-type-specific interactome analysis
(Mary Ann Liebert, 2022)Multiple sclerosis (MS) is a demyelinating disorder that affects multiple regions of the central nervous system such as the brain, spinal cord, and optic nerves. Susceptibility to MS, as well as disease progression rates, ... -
Mutant SOD1 protein increases Na(v)1.3 channel excitability
(Springer, 2016)Amyotrophic lateral sclerosis (ALS) is a lethal paralytic disease caused by the degeneration of motor neurons in the spinal cord, brain stem, and motor cortex. Mutations in the gene encoding copper/zinc superoxide dismutase ...
